Cargando…
Bowel preparation efficacy and safety of compound polyethylene glycol electrolyte powder combined with linaclotide for colonoscopy: A randomized controlled trial
BACKGROUND AND AIM: Adequate bowel preparation is essential for colonoscopy, which is important for detecting colon polyps and preventing colorectal cancer. Linaclotide is approved for irritable bowel syndrome with predominant constipation (IBS‐C) symptoms. The main objective of this study was to ex...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Publishing Asia Pty Ltd
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517441/ https://www.ncbi.nlm.nih.gov/pubmed/37744708 http://dx.doi.org/10.1002/jgh3.12961 |
_version_ | 1785109321378430976 |
---|---|
author | Yang, Jing Wei, Qian Xiang, Zhixiong Wu, Dangyan Lin, Zhuoying |
author_facet | Yang, Jing Wei, Qian Xiang, Zhixiong Wu, Dangyan Lin, Zhuoying |
author_sort | Yang, Jing |
collection | PubMed |
description | BACKGROUND AND AIM: Adequate bowel preparation is essential for colonoscopy, which is important for detecting colon polyps and preventing colorectal cancer. Linaclotide is approved for irritable bowel syndrome with predominant constipation (IBS‐C) symptoms. The main objective of this study was to explore the quality of bowel preparation by low‐volume compound polyethylene glycol (PEG) combined with linaclotide. METHODS: A total of 266 patients who underwent colonoscopy in Shangrao People's Hospital from June 2021 to June 2022 were randomized to 1 of 3 split PEG regimens: 4LPEG, 2LPEG, and 2LPEG + L (linaclotide). The primary end point was adequate bowel preparation (Boston Bowel Preparation Scale [BBPS] total score of ≥6, with each of three colonic segments subscores ≥2). Secondary outcomes were polyp detection rates and the incidence of adverse reactions. RESULTS: Over 12 months, 266 subjects were randomized into 2LPEG (n = 12), 4LPEG (n = 112), or 2LPEG + L (n = 142). There were no significant differences between the 4LPEG and 2LPEG + L groups in achieving adequate bowel preparation (P > 0.05). The mean BBPS score of the total colon, left hemi‐colon, right hemi‐colon, and transverse in the 2LPEG + L group was higher than that in the 2LPEG group (P < 0.001). Patient's sleeping quality and the incidence of adverse reactions of 2LPEG + L group were compatible with 2LPEG group, but it was significantly lower than that in 4LPEG group. There was no statistically significant difference in the detection rate of colon polyps between each group. CONCLUSION: The quality of bowel preparation of the compound polyethylene glycol electrolyte powder combined with linaclotide is approximately the same as that of 4LPEG, and it can reduce the adverse reactions in the process of bowel preparation, and its intestinal cleansing effect is also better than that of 2LPEG. |
format | Online Article Text |
id | pubmed-10517441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wiley Publishing Asia Pty Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-105174412023-09-24 Bowel preparation efficacy and safety of compound polyethylene glycol electrolyte powder combined with linaclotide for colonoscopy: A randomized controlled trial Yang, Jing Wei, Qian Xiang, Zhixiong Wu, Dangyan Lin, Zhuoying JGH Open Original Articles BACKGROUND AND AIM: Adequate bowel preparation is essential for colonoscopy, which is important for detecting colon polyps and preventing colorectal cancer. Linaclotide is approved for irritable bowel syndrome with predominant constipation (IBS‐C) symptoms. The main objective of this study was to explore the quality of bowel preparation by low‐volume compound polyethylene glycol (PEG) combined with linaclotide. METHODS: A total of 266 patients who underwent colonoscopy in Shangrao People's Hospital from June 2021 to June 2022 were randomized to 1 of 3 split PEG regimens: 4LPEG, 2LPEG, and 2LPEG + L (linaclotide). The primary end point was adequate bowel preparation (Boston Bowel Preparation Scale [BBPS] total score of ≥6, with each of three colonic segments subscores ≥2). Secondary outcomes were polyp detection rates and the incidence of adverse reactions. RESULTS: Over 12 months, 266 subjects were randomized into 2LPEG (n = 12), 4LPEG (n = 112), or 2LPEG + L (n = 142). There were no significant differences between the 4LPEG and 2LPEG + L groups in achieving adequate bowel preparation (P > 0.05). The mean BBPS score of the total colon, left hemi‐colon, right hemi‐colon, and transverse in the 2LPEG + L group was higher than that in the 2LPEG group (P < 0.001). Patient's sleeping quality and the incidence of adverse reactions of 2LPEG + L group were compatible with 2LPEG group, but it was significantly lower than that in 4LPEG group. There was no statistically significant difference in the detection rate of colon polyps between each group. CONCLUSION: The quality of bowel preparation of the compound polyethylene glycol electrolyte powder combined with linaclotide is approximately the same as that of 4LPEG, and it can reduce the adverse reactions in the process of bowel preparation, and its intestinal cleansing effect is also better than that of 2LPEG. Wiley Publishing Asia Pty Ltd 2023-08-31 /pmc/articles/PMC10517441/ /pubmed/37744708 http://dx.doi.org/10.1002/jgh3.12961 Text en © 2023 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Yang, Jing Wei, Qian Xiang, Zhixiong Wu, Dangyan Lin, Zhuoying Bowel preparation efficacy and safety of compound polyethylene glycol electrolyte powder combined with linaclotide for colonoscopy: A randomized controlled trial |
title | Bowel preparation efficacy and safety of compound polyethylene glycol electrolyte powder combined with linaclotide for colonoscopy: A randomized controlled trial |
title_full | Bowel preparation efficacy and safety of compound polyethylene glycol electrolyte powder combined with linaclotide for colonoscopy: A randomized controlled trial |
title_fullStr | Bowel preparation efficacy and safety of compound polyethylene glycol electrolyte powder combined with linaclotide for colonoscopy: A randomized controlled trial |
title_full_unstemmed | Bowel preparation efficacy and safety of compound polyethylene glycol electrolyte powder combined with linaclotide for colonoscopy: A randomized controlled trial |
title_short | Bowel preparation efficacy and safety of compound polyethylene glycol electrolyte powder combined with linaclotide for colonoscopy: A randomized controlled trial |
title_sort | bowel preparation efficacy and safety of compound polyethylene glycol electrolyte powder combined with linaclotide for colonoscopy: a randomized controlled trial |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517441/ https://www.ncbi.nlm.nih.gov/pubmed/37744708 http://dx.doi.org/10.1002/jgh3.12961 |
work_keys_str_mv | AT yangjing bowelpreparationefficacyandsafetyofcompoundpolyethyleneglycolelectrolytepowdercombinedwithlinaclotideforcolonoscopyarandomizedcontrolledtrial AT weiqian bowelpreparationefficacyandsafetyofcompoundpolyethyleneglycolelectrolytepowdercombinedwithlinaclotideforcolonoscopyarandomizedcontrolledtrial AT xiangzhixiong bowelpreparationefficacyandsafetyofcompoundpolyethyleneglycolelectrolytepowdercombinedwithlinaclotideforcolonoscopyarandomizedcontrolledtrial AT wudangyan bowelpreparationefficacyandsafetyofcompoundpolyethyleneglycolelectrolytepowdercombinedwithlinaclotideforcolonoscopyarandomizedcontrolledtrial AT linzhuoying bowelpreparationefficacyandsafetyofcompoundpolyethyleneglycolelectrolytepowdercombinedwithlinaclotideforcolonoscopyarandomizedcontrolledtrial |