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Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls
BACKGROUND: Epidemiologic evidence suggests that environmental factors acting as endocrine disrupting chemicals (EDCs) are associated with mammographic breast density and the risk of breast cancer. Exposure to EDCs during puberty, a period of rapid breast development, may affect susceptibility to br...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517447/ https://www.ncbi.nlm.nih.gov/pubmed/36302292 http://dx.doi.org/10.1016/j.envint.2022.107586 |
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author | Yoon, Lara S. Binder, Alexandra M. Pereira, Ana Calafat, Antonia M. Shepherd, John Corvalán, Camila Michels, Karin B. |
author_facet | Yoon, Lara S. Binder, Alexandra M. Pereira, Ana Calafat, Antonia M. Shepherd, John Corvalán, Camila Michels, Karin B. |
author_sort | Yoon, Lara S. |
collection | PubMed |
description | BACKGROUND: Epidemiologic evidence suggests that environmental factors acting as endocrine disrupting chemicals (EDCs) are associated with mammographic breast density and the risk of breast cancer. Exposure to EDCs during puberty, a period of rapid breast development, may affect susceptibility to breast carcinogenesis. METHODS: In a cohort of 366 Chilean adolescents from the Growth and Obesity Cohort Study, we evaluated the relation between urinary concentrations of 15 suspected EDC biomarkers across three pubertal time points (Tanner breast stage 1 (B1), 4 (B4), and 1-year post-menarche) and breast fibroglandular volume (FGV; percent FGV [%FGV] and absolute FGV [aFGV]) and total breast volume (tBV) at 2-years post-menarche. We used linear mixed models to test differences in creatinine-corrected EDC biomarker concentrations at B4 and 1-year post-menarche compared to B1 and calculated intraclass correlation coefficients (ICC) of EDC concentrations across time points to appraise the consistency of measurements. We fit multivariable generalized estimating equations (GEEs) to evaluate windows of susceptibility for the association between log(10)-transformed EDCs and log(10)-transformed breast outcomes. GEEs were adjusted for age, body fat percentage, total caloric intake, and maternal education. RESULTS: Urinary EDC biomarker concentrations highly varied across pubertal time points (ICC range 0.01–0.30). For 12 EDCs, biomarker concentrations decreased over time. Triclosan measured at 1-year post-menarche was inversely associated with %FGV at 2-years post-menarche (β = −0.025, 95 % confidence interval = −0.041, −0.008). Mono(2-ethyl-5-carboxypentyl) phthalate and the sum of di(2-ethylhexyl) phthalate metabolite concentrations at B4 were positively associated with aFGV and tBV at 2-years post-menarche. No measured phenols were associated with aFGV and tBV, while no measured parabens were associated with %FGV and aFGV. CONCLUSIONS: Our study suggests relatively high variability in EDC biomarker concentrations across the peripubertal time period. We also found evidence to suggest that there may be pubertal windows of susceptibility to select EDCs for the association with adolescent breast density. |
format | Online Article Text |
id | pubmed-10517447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-105174472023-09-23 Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls Yoon, Lara S. Binder, Alexandra M. Pereira, Ana Calafat, Antonia M. Shepherd, John Corvalán, Camila Michels, Karin B. Environ Int Article BACKGROUND: Epidemiologic evidence suggests that environmental factors acting as endocrine disrupting chemicals (EDCs) are associated with mammographic breast density and the risk of breast cancer. Exposure to EDCs during puberty, a period of rapid breast development, may affect susceptibility to breast carcinogenesis. METHODS: In a cohort of 366 Chilean adolescents from the Growth and Obesity Cohort Study, we evaluated the relation between urinary concentrations of 15 suspected EDC biomarkers across three pubertal time points (Tanner breast stage 1 (B1), 4 (B4), and 1-year post-menarche) and breast fibroglandular volume (FGV; percent FGV [%FGV] and absolute FGV [aFGV]) and total breast volume (tBV) at 2-years post-menarche. We used linear mixed models to test differences in creatinine-corrected EDC biomarker concentrations at B4 and 1-year post-menarche compared to B1 and calculated intraclass correlation coefficients (ICC) of EDC concentrations across time points to appraise the consistency of measurements. We fit multivariable generalized estimating equations (GEEs) to evaluate windows of susceptibility for the association between log(10)-transformed EDCs and log(10)-transformed breast outcomes. GEEs were adjusted for age, body fat percentage, total caloric intake, and maternal education. RESULTS: Urinary EDC biomarker concentrations highly varied across pubertal time points (ICC range 0.01–0.30). For 12 EDCs, biomarker concentrations decreased over time. Triclosan measured at 1-year post-menarche was inversely associated with %FGV at 2-years post-menarche (β = −0.025, 95 % confidence interval = −0.041, −0.008). Mono(2-ethyl-5-carboxypentyl) phthalate and the sum of di(2-ethylhexyl) phthalate metabolite concentrations at B4 were positively associated with aFGV and tBV at 2-years post-menarche. No measured phenols were associated with aFGV and tBV, while no measured parabens were associated with %FGV and aFGV. CONCLUSIONS: Our study suggests relatively high variability in EDC biomarker concentrations across the peripubertal time period. We also found evidence to suggest that there may be pubertal windows of susceptibility to select EDCs for the association with adolescent breast density. 2022-12 2022-10-19 /pmc/articles/PMC10517447/ /pubmed/36302292 http://dx.doi.org/10.1016/j.envint.2022.107586 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Yoon, Lara S. Binder, Alexandra M. Pereira, Ana Calafat, Antonia M. Shepherd, John Corvalán, Camila Michels, Karin B. Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls |
title | Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls |
title_full | Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls |
title_fullStr | Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls |
title_full_unstemmed | Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls |
title_short | Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls |
title_sort | variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in chilean girls |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517447/ https://www.ncbi.nlm.nih.gov/pubmed/36302292 http://dx.doi.org/10.1016/j.envint.2022.107586 |
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