Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia

In KMT2A-rearranged acute lymphoblastic leukemia (ALL), an aggressive malignancy, oncogenic KMT2A-fusion proteins inappropriately recruit DOT1L to promote leukemogenesis, highlighting DOT1L as an attractive therapeutic target. Unfortunately, treatment with the first-in-class DOT1L inhibitor pinometo...

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Detalles Bibliográficos
Autores principales: Schneider, Pauline, Crump, Nicholas T., Arentsen-Peters, Susan T.C.J.M., Smith, Alastair L., Hagelaar, Rico, Adriaanse, Fabienne R.S., Bos, Romy S., de Jong, Anja, Nierkens, Stefan, Koopmans, Bianca, Milne, Thomas A., Pieters, Rob, Stam, Ronald W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517487/
https://www.ncbi.nlm.nih.gov/pubmed/37740239
http://dx.doi.org/10.1186/s40164-023-00445-8

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