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Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound

BACKGROUND: The dense stroma of pancreatic ductal adenocarcinomas is a major barrier to drug delivery. To increase the local drug diffusion gradient, high doses of chemotherapeutic agent doxorubicin can be released from thermally-sensitive liposomes (ThermoDox®) using ultrasound-mediated hyperthermi...

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Detalles Bibliográficos
Autores principales:	Spiers, Laura, Gray, Michael, Lyon, Paul, Sivakumar, Shivan, Bekkali, Noor, Scott, Shaun, Collins, Linda, Carlisle, Robert, Wu, Feng, Middleton, Mark, Coussios, Constantin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517508/ https://www.ncbi.nlm.nih.gov/pubmed/37741968 http://dx.doi.org/10.1186/s12885-023-11228-z

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