Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes

BACKGROUND: Polymorphic ventricular tachycardia (PMVT) is a rare genetic disease associated with structurally normal hearts which in 8% of cases can lead to sudden cardiac death, typically exercise-induced. We previously showed a link between the RyR2-H29D mutation and a clinical phenotype of short-...

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Detalles Bibliográficos
Autores principales: Sleiman, Yvonne, Reiken, Steven, Charrabi, Azzouz, Jaffré, Fabrice, Sittenfeld, Leah R., Pasquié, Jean-Luc, Colombani, Sarah, Lerman, Bruce B., Chen, Shuibing, Marks, Andrew R., Cheung, Jim W., Evans, Todd, Lacampagne, Alain, Meli, Albano C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517551/
https://www.ncbi.nlm.nih.gov/pubmed/37740238
http://dx.doi.org/10.1186/s13287-023-03502-5

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