Cargando…

The enigmatic ear: Unveiling a rare case of a primary cutaneous CD8+ acral T-cell lymphoproliferative disorder with a literature review

Introduction: Primary cutaneous CD8+ acral T-cell lymphoproliferative disorder (CD8+ ATCLPD) is a rare form of cutaneous T-cell lymphoma that commonly presents on the acral regions of the body. We report a case of a 61-year-old man diagnosed with primary cutaneous CD8+ ATCLPD of the ear. Case presen...

Descripción completa

Detalles Bibliográficos
Autores principales: Sahraoui, Ghada, Sassi, Farah, Charfi, Lamia, Doghri, Raoudha, Mrad, Karima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517602/
https://www.ncbi.nlm.nih.gov/pubmed/37743904
http://dx.doi.org/10.1177/20363613231204046
_version_ 1785109358791622656
author Sahraoui, Ghada
Sassi, Farah
Charfi, Lamia
Doghri, Raoudha
Mrad, Karima
author_facet Sahraoui, Ghada
Sassi, Farah
Charfi, Lamia
Doghri, Raoudha
Mrad, Karima
author_sort Sahraoui, Ghada
collection PubMed
description Introduction: Primary cutaneous CD8+ acral T-cell lymphoproliferative disorder (CD8+ ATCLPD) is a rare form of cutaneous T-cell lymphoma that commonly presents on the acral regions of the body. We report a case of a 61-year-old man diagnosed with primary cutaneous CD8+ ATCLPD of the ear. Case presentation: A 61-year-old man presented with a non-healing, erythematous painful macule on the ear that had been evolving for the past 3 months. The lesion was resected, and histopathological examination revealed a primary cutaneous CD8+ ATCLPD with acral localization. Further investigations including CT scan of the thorax, abdomen and pelvis were done to stage the disease. The results showed no extracutaneous involvement. Conclusion: Accurate identification of primary cutaneous CD8+ ATCLPD is crucial due to its distinct prognostic and therapeutic implications compared to other CD8+ cytotoxic lymphoid proliferations. Primary cutaneous CD8+ ATCLPD can be treated conservatively and typically follows a slow clinical course, regardless of the treatment method. Understanding the clinical context, as well as the morphological and immunophenotypic characteristics, can assist in making a precise diagnosis.
format Online
Article
Text
id pubmed-10517602
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-105176022023-09-24 The enigmatic ear: Unveiling a rare case of a primary cutaneous CD8+ acral T-cell lymphoproliferative disorder with a literature review Sahraoui, Ghada Sassi, Farah Charfi, Lamia Doghri, Raoudha Mrad, Karima Rare Tumors Case Report Introduction: Primary cutaneous CD8+ acral T-cell lymphoproliferative disorder (CD8+ ATCLPD) is a rare form of cutaneous T-cell lymphoma that commonly presents on the acral regions of the body. We report a case of a 61-year-old man diagnosed with primary cutaneous CD8+ ATCLPD of the ear. Case presentation: A 61-year-old man presented with a non-healing, erythematous painful macule on the ear that had been evolving for the past 3 months. The lesion was resected, and histopathological examination revealed a primary cutaneous CD8+ ATCLPD with acral localization. Further investigations including CT scan of the thorax, abdomen and pelvis were done to stage the disease. The results showed no extracutaneous involvement. Conclusion: Accurate identification of primary cutaneous CD8+ ATCLPD is crucial due to its distinct prognostic and therapeutic implications compared to other CD8+ cytotoxic lymphoid proliferations. Primary cutaneous CD8+ ATCLPD can be treated conservatively and typically follows a slow clinical course, regardless of the treatment method. Understanding the clinical context, as well as the morphological and immunophenotypic characteristics, can assist in making a precise diagnosis. SAGE Publications 2023-09-22 /pmc/articles/PMC10517602/ /pubmed/37743904 http://dx.doi.org/10.1177/20363613231204046 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Sahraoui, Ghada
Sassi, Farah
Charfi, Lamia
Doghri, Raoudha
Mrad, Karima
The enigmatic ear: Unveiling a rare case of a primary cutaneous CD8+ acral T-cell lymphoproliferative disorder with a literature review
title The enigmatic ear: Unveiling a rare case of a primary cutaneous CD8+ acral T-cell lymphoproliferative disorder with a literature review
title_full The enigmatic ear: Unveiling a rare case of a primary cutaneous CD8+ acral T-cell lymphoproliferative disorder with a literature review
title_fullStr The enigmatic ear: Unveiling a rare case of a primary cutaneous CD8+ acral T-cell lymphoproliferative disorder with a literature review
title_full_unstemmed The enigmatic ear: Unveiling a rare case of a primary cutaneous CD8+ acral T-cell lymphoproliferative disorder with a literature review
title_short The enigmatic ear: Unveiling a rare case of a primary cutaneous CD8+ acral T-cell lymphoproliferative disorder with a literature review
title_sort enigmatic ear: unveiling a rare case of a primary cutaneous cd8+ acral t-cell lymphoproliferative disorder with a literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517602/
https://www.ncbi.nlm.nih.gov/pubmed/37743904
http://dx.doi.org/10.1177/20363613231204046
work_keys_str_mv AT sahraouighada theenigmaticearunveilingararecaseofaprimarycutaneouscd8acraltcelllymphoproliferativedisorderwithaliteraturereview
AT sassifarah theenigmaticearunveilingararecaseofaprimarycutaneouscd8acraltcelllymphoproliferativedisorderwithaliteraturereview
AT charfilamia theenigmaticearunveilingararecaseofaprimarycutaneouscd8acraltcelllymphoproliferativedisorderwithaliteraturereview
AT doghriraoudha theenigmaticearunveilingararecaseofaprimarycutaneouscd8acraltcelllymphoproliferativedisorderwithaliteraturereview
AT mradkarima theenigmaticearunveilingararecaseofaprimarycutaneouscd8acraltcelllymphoproliferativedisorderwithaliteraturereview
AT sahraouighada enigmaticearunveilingararecaseofaprimarycutaneouscd8acraltcelllymphoproliferativedisorderwithaliteraturereview
AT sassifarah enigmaticearunveilingararecaseofaprimarycutaneouscd8acraltcelllymphoproliferativedisorderwithaliteraturereview
AT charfilamia enigmaticearunveilingararecaseofaprimarycutaneouscd8acraltcelllymphoproliferativedisorderwithaliteraturereview
AT doghriraoudha enigmaticearunveilingararecaseofaprimarycutaneouscd8acraltcelllymphoproliferativedisorderwithaliteraturereview
AT mradkarima enigmaticearunveilingararecaseofaprimarycutaneouscd8acraltcelllymphoproliferativedisorderwithaliteraturereview