A subset of type-II collagen-binding antibodies prevents experimental arthritis by inhibiting FCGR3 signaling in neutrophils

Rheumatoid arthritis (RA) involves several classes of pathogenic autoantibodies, some of which react with type-II collagen (COL2) in articular cartilage. We previously described a subset of COL2 antibodies targeting the F4 epitope (ERGLKGHRGFT) that could be regulatory. Here, using phage display, we...

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Detalles Bibliográficos
Autores principales: Xu, Zhongwei, Xu, Bingze, Lundström, Susanna L., Moreno-Giró, Àlex, Zhao, Danxia, Martin, Myriam, Lönnblom, Erik, Li, Qixing, Krämer, Alexander, Ge, Changrong, Cheng, Lei, Liang, Bibo, Tong, Dongmei, Stawikowska, Roma, Blom, Anna M., Fields, Gregg B., Zubarev, Roman A., Holmdahl, Rikard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517938/
https://www.ncbi.nlm.nih.gov/pubmed/37741824
http://dx.doi.org/10.1038/s41467-023-41561-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517938/
https://www.ncbi.nlm.nih.gov/pubmed/37741824
http://dx.doi.org/10.1038/s41467-023-41561-7

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