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Single-chain dimers from de novo immunoglobulins as robust scaffolds for multiple binding loops
Antibody derivatives have sought to recapitulate the antigen binding properties of antibodies, but with improved biophysical attributes convenient for therapeutic, diagnostic and research applications. However, their success has been limited by the naturally occurring structure of the immunoglobulin...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517939/ https://www.ncbi.nlm.nih.gov/pubmed/37741853 http://dx.doi.org/10.1038/s41467-023-41717-5 |