Integrated Transcriptome Analysis of Long Noncoding RNA and mRNA in Developing and Aging Mouse Retina

Mice have emerged as a widely employed model for investigating various retinal diseases. However, the availability of comprehensive datasets capturing the entire developmental and aging stages of the mouse retina, particularly during the elderly period, encompassing integrated lncRNA and mRNA expres...

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Autores principales: Kong, Kangjie, Wang, Peiyuan, Xie, Zihong, Wang, Lu, Jiang, Jiaxuan, Liu, Yaoming, Du, Shaolin, Jiang, Jingwen, Song, Yunhe, Lin, Fengbin, Wang, Wei, Fang, Xiuli, Shi, Zhuoxing, Zhang, Xiulan, Chen, Shida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Data Descriptor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518015/
https://www.ncbi.nlm.nih.gov/pubmed/37741836
http://dx.doi.org/10.1038/s41597-023-02562-9
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author Kong, Kangjie
Wang, Peiyuan
Xie, Zihong
Wang, Lu
Jiang, Jiaxuan
Liu, Yaoming
Du, Shaolin
Jiang, Jingwen
Song, Yunhe
Lin, Fengbin
Wang, Wei
Fang, Xiuli
Shi, Zhuoxing
Zhang, Xiulan
Chen, Shida
author_facet Kong, Kangjie
Wang, Peiyuan
Xie, Zihong
Wang, Lu
Jiang, Jiaxuan
Liu, Yaoming
Du, Shaolin
Jiang, Jingwen
Song, Yunhe
Lin, Fengbin
Wang, Wei
Fang, Xiuli
Shi, Zhuoxing
Zhang, Xiulan
Chen, Shida
author_sort Kong, Kangjie
collection PubMed
description Mice have emerged as a widely employed model for investigating various retinal diseases. However, the availability of comprehensive datasets capturing the entire developmental and aging stages of the mouse retina, particularly during the elderly period, encompassing integrated lncRNA and mRNA expression profiles, is limited. In this study, we assembled a total of 18 retina samples from mice across 6 distinct stages of development and aging (5 days, 3 weeks, 6 weeks, 10 weeks, 6 months, and 15 months) to conduct integrated lncRNA and mRNA sequencing analysis. This invaluable dataset offers a comprehensive transcriptomic resource of mRNA and lncRNA expression profiles during the natural progression of retinal development and aging. The discoveries stemming from this investigation will significantly contribute to the elucidation of the underlying molecular mechanisms associated with various retinal diseases, such as congenital retinal dysplasia and retinal degenerative diseases.
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spelling pubmed-105180152023-09-25 Integrated Transcriptome Analysis of Long Noncoding RNA and mRNA in Developing and Aging Mouse Retina Kong, Kangjie Wang, Peiyuan Xie, Zihong Wang, Lu Jiang, Jiaxuan Liu, Yaoming Du, Shaolin Jiang, Jingwen Song, Yunhe Lin, Fengbin Wang, Wei Fang, Xiuli Shi, Zhuoxing Zhang, Xiulan Chen, Shida Sci Data Data Descriptor Mice have emerged as a widely employed model for investigating various retinal diseases. However, the availability of comprehensive datasets capturing the entire developmental and aging stages of the mouse retina, particularly during the elderly period, encompassing integrated lncRNA and mRNA expression profiles, is limited. In this study, we assembled a total of 18 retina samples from mice across 6 distinct stages of development and aging (5 days, 3 weeks, 6 weeks, 10 weeks, 6 months, and 15 months) to conduct integrated lncRNA and mRNA sequencing analysis. This invaluable dataset offers a comprehensive transcriptomic resource of mRNA and lncRNA expression profiles during the natural progression of retinal development and aging. The discoveries stemming from this investigation will significantly contribute to the elucidation of the underlying molecular mechanisms associated with various retinal diseases, such as congenital retinal dysplasia and retinal degenerative diseases. Nature Publishing Group UK 2023-09-23 /pmc/articles/PMC10518015/ /pubmed/37741836 http://dx.doi.org/10.1038/s41597-023-02562-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Data Descriptor
Kong, Kangjie
Wang, Peiyuan
Xie, Zihong
Wang, Lu
Jiang, Jiaxuan
Liu, Yaoming
Du, Shaolin
Jiang, Jingwen
Song, Yunhe
Lin, Fengbin
Wang, Wei
Fang, Xiuli
Shi, Zhuoxing
Zhang, Xiulan
Chen, Shida
Integrated Transcriptome Analysis of Long Noncoding RNA and mRNA in Developing and Aging Mouse Retina
title Integrated Transcriptome Analysis of Long Noncoding RNA and mRNA in Developing and Aging Mouse Retina
title_full Integrated Transcriptome Analysis of Long Noncoding RNA and mRNA in Developing and Aging Mouse Retina
title_fullStr Integrated Transcriptome Analysis of Long Noncoding RNA and mRNA in Developing and Aging Mouse Retina
title_full_unstemmed Integrated Transcriptome Analysis of Long Noncoding RNA and mRNA in Developing and Aging Mouse Retina
title_short Integrated Transcriptome Analysis of Long Noncoding RNA and mRNA in Developing and Aging Mouse Retina
title_sort integrated transcriptome analysis of long noncoding rna and mrna in developing and aging mouse retina
topic Data Descriptor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518015/
https://www.ncbi.nlm.nih.gov/pubmed/37741836
http://dx.doi.org/10.1038/s41597-023-02562-9
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