DNA methylation regulator-mediated modification patterns and risk of intracranial aneurysm: a multi-omics and epigenome-wide association study integrating machine learning, Mendelian randomization, eQTL and mQTL data

BACKGROUND: Intracranial aneurysms (IAs) pose a significant and intricate challenge. Elucidating the interplay between DNA methylation and IA pathogenesis is paramount to identify potential biomarkers and therapeutic interventions. METHODS: We employed a comprehensive bioinformatics investigation of...

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Detalles Bibliográficos
Autores principales: Maimaiti, Aierpati, Turhon, Mirzat, Abulaiti, Aimitaji, Dilixiati, Yilidanna, Zhang, Fujunhui, Axieer, Aximujiang, Kadeer, Kaheerman, Zhang, Yisen, Maimaitili, Aisha, Yang, Xinjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518114/
https://www.ncbi.nlm.nih.gov/pubmed/37742034
http://dx.doi.org/10.1186/s12967-023-04512-w

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