Cargando…

The antihypertensive felodipine shows synergistic activity with immune checkpoint blockade and inhibits tumor growth via NFAT1 in LUSC

This study aimed to explore the role and mechanism of felodipine in lung cancer therapy. Murine subcutaneous lung squamous cancer (LUSC) models constructed by KLN-205 cells were utilized to assess the effect of felodipine monotherapy and in combination with the programmed cell death protein 1 antibo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Si-Yu, Xiao, Hong-Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	De Gruyter 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518203/ https://www.ncbi.nlm.nih.gov/pubmed/37750075 http://dx.doi.org/10.1515/med-2023-0801

Ejemplares similares

NF-YA Overexpression in Lung Cancer: LUSC
por: Bezzecchi, Eugenia, et al.
Publicado: (2019)

Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment
por: Yi, Ming, et al.
Publicado: (2019)

Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer
por: Zhu, Shaoming, et al.
Publicado: (2021)

The Synergistic Effect of Immune Checkpoint Blockade and Radiotherapy in Recurrent/Metastatic Sinonasal Cancer
por: Yazici, Gozde, et al.
Publicado: (2018)

Nanovesicles for transdermal delivery of felodipine: Development, characterization, and pharmacokinetics
por: Yusuf, Mohd, et al.
Publicado: (2014)

Effect of felodipine on indomethacin-induced gastric ulcers in rats
por: Akbaş, Nergis, et al.
Publicado: (2023)

Differentiated regulation of immune-response related genes between LUAD and LUSC subtypes of lung cancers
por: Chen, Mengzhu, et al.
Publicado: (2016)

Prospects for combining immune checkpoint blockade with PARP inhibition
por: Li, Anping, et al.
Publicado: (2019)

Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
por: Siddiqi, Farah H., et al.
Publicado: (2019)

Exploring molecular reorientations in amorphous and recrystallized felodipine at the microscopic level
por: Pajzderska, A., et al.
Publicado: (2020)

YIV-906 enhances nuclear factor of activated T-cells (NFAT) activity of T cells and promotes immune checkpoint blockade antibody action and CAR T-cell activity
por: Lam, Wing, et al.
Publicado: (2023)

Corticosteroids and immune checkpoint blockade
por: Min, Le, et al.
Publicado: (2015)

Immune checkpoint blockade in HIV
por: Gubser, Celine, et al.
Publicado: (2022)

Molecular subtypes of oropharyngeal cancer show distinct immune microenvironment related with immune checkpoint blockade response
por: Kim, Min Hwan, et al.
Publicado: (2020)

Development of a reservoir type prolonged release system with felodipine via simplex methodology
por: IOVANOV, RAREŞ IULIU, et al.
Publicado: (2016)

Network pharmacology and bioinformatics analysis identifies potential therapeutic targets of Naringenin against COVID-19/LUSC
por: Wu, Wen-yu, et al.
Publicado: (2023)

Correction: Molecular subtypes of oropharyngeal cancer show distinct immune microenvironment related with immune checkpoint blockade response
por: Kim, Min Hwan, et al.
Publicado: (2020)

Identification of the key genes and characterizations of Tumor Immune Microenvironment in Lung Adenocarcinoma (LUAD) and Lung Squamous Cell Carcinoma (LUSC)
por: Zhang, Lemeng, et al.
Publicado: (2020)

Immune checkpoint blockade in ovarian cancer
por: Weiss, Lukas, et al.
Publicado: (2016)

Hallmarks of response to immune checkpoint blockade
por: Cogdill, Alexandria P, et al.
Publicado: (2017)

Immune-Checkpoint Blockade Therapy in Lymphoma
por: Kuzume, Ayumi, et al.
Publicado: (2020)

Activation of phagocytosis by immune checkpoint blockade
por: Li, Chia-Wei, et al.
Publicado: (2018)

Neutrophils in the era of immune checkpoint blockade
por: Faget, Julien, et al.
Publicado: (2021)

MCT4 blockade increases the efficacy of immune checkpoint blockade
por: Babl, Nathalie, et al.
Publicado: (2023)

Protective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice
por: Tanaka, Ken-ichiro, et al.
Publicado: (2017)

Author Correction: Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
por: Siddiqi, Farah H., et al.
Publicado: (2019)

Felodipine Determination by a CdTe Quantum Dot-Based Fluorescent Probe
por: Lv, Yuguang, et al.
Publicado: (2022)

The value of CEP55 gene as a diagnostic biomarker and independent prognostic factor in LUAD and LUSC
por: Fu, Linhai, et al.
Publicado: (2020)

Dissecting the Immunological Profiles in NSD3-Amplified LUSC through Integrative Multi-Scale Analyses
por: Xu, Duo, et al.
Publicado: (2022)

Construction and validation of a cuproptosis-related lncRNA signature for the prediction of the prognosis of LUAD and LUSC
por: Wang, Yu, et al.
Publicado: (2023)

Multi-Omics Analysis of the Anti-tumor Synergistic Mechanism and Potential Application of Immune Checkpoint Blockade Combined With Lenvatinib
por: Lu, Yuting, et al.
Publicado: (2021)

Reverse Translation Identifies the Synergistic Role of Immune Checkpoint Blockade and IL15 to Enhance Immunotherapy of Ovarian Cancer
por: Felices, Martin, et al.
Publicado: (2023)

Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade
por: Dmello, Crismita, et al.
Publicado: (2023)

The combination of eddy thermal effect of biodegradable magnesium with immune checkpoint blockade shows enhanced efficacy against osteosarcoma
por: Ge, Jun, et al.
Publicado: (2023)

Immune Checkpoint Inhibition–Related Myasthenia-Myositis-Myocarditis Responsive to Complement Blockade
por: Nelke, Christopher, et al.
Publicado: (2023)

Overcoming immune checkpoint blockade resistance in solid tumors with intermittent ITK inhibition
por: Zhao, Manzhi, et al.
Publicado: (2023)

Synchronous fluorescence spectrofluorimetric method for the simultaneous determination of metoprolol and felodipine in combined pharmaceutical preparation
por: Walash, Mohamed I, et al.
Publicado: (2011)

Gingival Enlargement Induced by Felodipine Resolves with a Conventional Periodontal Treatment and Drug Modification
por: Khzam, Nabil, et al.
Publicado: (2016)

Immune-Checkpoint Blockade and Active Immunotherapy for Glioma
por: Ahn, Brian J., et al.
Publicado: (2013)

The Puzzle of Predicting Response to Immune Checkpoint Blockade
por: Onyshchenko, Mykola
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_66ldge1c0kg7s5m607bu8npq95