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Waldenstrom Macroglobulinemia: Clinical Presentation, Diagnosis, and Management in an Elderly Male

Waldenstrom macroglobulinemia (WM) is a rare lymphoproliferative disease that can have an ambiguous clinical presentation. A key component of the pathophysiology of WM is bone marrow infiltration, which most commonly presents as anemia. Other symptoms of WM tend to be generalized and non-specific, w...

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Autores principales: Shahab, Shahman, Semerdzhiev, Dimitar I, Reeves, James, Daniel, Amy, Martin, David E, Sukpraprut-Braaten, Suporn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518236/
https://www.ncbi.nlm.nih.gov/pubmed/37750145
http://dx.doi.org/10.7759/cureus.44127
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author Shahab, Shahman
Semerdzhiev, Dimitar I
Reeves, James
Daniel, Amy
Martin, David E
Sukpraprut-Braaten, Suporn
author_facet Shahab, Shahman
Semerdzhiev, Dimitar I
Reeves, James
Daniel, Amy
Martin, David E
Sukpraprut-Braaten, Suporn
author_sort Shahab, Shahman
collection PubMed
description Waldenstrom macroglobulinemia (WM) is a rare lymphoproliferative disease that can have an ambiguous clinical presentation. A key component of the pathophysiology of WM is bone marrow infiltration, which most commonly presents as anemia. Other symptoms of WM tend to be generalized and non-specific, which presents a diagnostic challenge. This was the case with our patient as well, when he presented to our outpatient clinic with non-specific symptoms. We present a 79-year-old male with longstanding pancytopenia, polyarthralgia, bilateral pedal edema, decreased appetite, and increased bleeding from wounds. The patient had a complete blood count (CBC) and complete metabolic panel (CMP) done, confirming present anemia, which prompted inpatient treatment and an oncology workup, confirming WM. The patient began a zanubrutinib monotherapy regimen, showing improvement in his pancytopenia, polyarthralgia, and overall symptoms.
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spelling pubmed-105182362023-09-25 Waldenstrom Macroglobulinemia: Clinical Presentation, Diagnosis, and Management in an Elderly Male Shahab, Shahman Semerdzhiev, Dimitar I Reeves, James Daniel, Amy Martin, David E Sukpraprut-Braaten, Suporn Cureus Family/General Practice Waldenstrom macroglobulinemia (WM) is a rare lymphoproliferative disease that can have an ambiguous clinical presentation. A key component of the pathophysiology of WM is bone marrow infiltration, which most commonly presents as anemia. Other symptoms of WM tend to be generalized and non-specific, which presents a diagnostic challenge. This was the case with our patient as well, when he presented to our outpatient clinic with non-specific symptoms. We present a 79-year-old male with longstanding pancytopenia, polyarthralgia, bilateral pedal edema, decreased appetite, and increased bleeding from wounds. The patient had a complete blood count (CBC) and complete metabolic panel (CMP) done, confirming present anemia, which prompted inpatient treatment and an oncology workup, confirming WM. The patient began a zanubrutinib monotherapy regimen, showing improvement in his pancytopenia, polyarthralgia, and overall symptoms. Cureus 2023-08-25 /pmc/articles/PMC10518236/ /pubmed/37750145 http://dx.doi.org/10.7759/cureus.44127 Text en Copyright © 2023, Shahab et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Family/General Practice
Shahab, Shahman
Semerdzhiev, Dimitar I
Reeves, James
Daniel, Amy
Martin, David E
Sukpraprut-Braaten, Suporn
Waldenstrom Macroglobulinemia: Clinical Presentation, Diagnosis, and Management in an Elderly Male
title Waldenstrom Macroglobulinemia: Clinical Presentation, Diagnosis, and Management in an Elderly Male
title_full Waldenstrom Macroglobulinemia: Clinical Presentation, Diagnosis, and Management in an Elderly Male
title_fullStr Waldenstrom Macroglobulinemia: Clinical Presentation, Diagnosis, and Management in an Elderly Male
title_full_unstemmed Waldenstrom Macroglobulinemia: Clinical Presentation, Diagnosis, and Management in an Elderly Male
title_short Waldenstrom Macroglobulinemia: Clinical Presentation, Diagnosis, and Management in an Elderly Male
title_sort waldenstrom macroglobulinemia: clinical presentation, diagnosis, and management in an elderly male
topic Family/General Practice
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518236/
https://www.ncbi.nlm.nih.gov/pubmed/37750145
http://dx.doi.org/10.7759/cureus.44127
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