Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC

Neoadjuvant chemotherapy can improve the survival of individuals with borderline and unresectable pancreatic ductal adenocarcinoma; however, heterogeneous responses to chemotherapy remain a significant clinical challenge. Here, we performed RNA sequencing (n = 97) and multiplexed immunofluorescence...

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Detalles Bibliográficos
Autores principales: Zhou, Xu, An, Jingyu, Kurilov, Roma, Brors, Benedikt, Hu, Kai, Peccerella, Teresa, Roessler, Stephanie, Pfütze, Katrin, Schulz, Angela, Wolf, Stephan, Hohmann, Nicolas, Theile, Dirk, Sauter, Max, Burhenne, Jürgen, Ei, Shigenori, Heger, Ulrike, Strobel, Oliver, Barry, Simon T., Springfeld, Christoph, Tjaden, Christine, Bergmann, Frank, Büchler, Markus, Hackert, Thilo, Fortunato, Franco, Neoptolemos, John P., Bailey, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518256/
https://www.ncbi.nlm.nih.gov/pubmed/37679568
http://dx.doi.org/10.1038/s43018-023-00628-6

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