NKD2 Trigger NF-κB Signaling Pathway and Facilitates Thyroid Cancer Cell Proliferation

NKD inhibitor of WNT signaling pathway 2 (NKD2) is an emerging player in cancer onset and progression. Here, it was confirmed that THCA patients have robustly expressed NKD2, which was linked to an advanced pathologic stage. The prognosis was worse for those with high NKD2 levels. Functionally, ecto...

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Autores principales: Ke, Shaoying, Pan, Qunxiong, Wang, Congren, Su, Zijian, Li, Mingzhu, Liu, Xiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518272/
https://www.ncbi.nlm.nih.gov/pubmed/36820951
http://dx.doi.org/10.1007/s12033-023-00665-7
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author Ke, Shaoying
Pan, Qunxiong
Wang, Congren
Su, Zijian
Li, Mingzhu
Liu, Xiaoyu
author_facet Ke, Shaoying
Pan, Qunxiong
Wang, Congren
Su, Zijian
Li, Mingzhu
Liu, Xiaoyu
author_sort Ke, Shaoying
collection PubMed
description NKD inhibitor of WNT signaling pathway 2 (NKD2) is an emerging player in cancer onset and progression. Here, it was confirmed that THCA patients have robustly expressed NKD2, which was linked to an advanced pathologic stage. The prognosis was worse for those with high NKD2 levels. Functionally, ectopically produced NKD2 promotes THCA cell proliferation, whereas NKD2 knockdown impairs the ability of THCA cells to proliferate. Mechanically, ectopically expressed NKD2 activated NF-κB transcriptional activity, whereas NKD2-deficient THCA cells showed lower NF-κB transcriptional activity. As a result, NKD2 activates the NF-κB signaling pathway, encouraging the growth of THCA cells.
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spelling pubmed-105182722023-09-26 NKD2 Trigger NF-κB Signaling Pathway and Facilitates Thyroid Cancer Cell Proliferation Ke, Shaoying Pan, Qunxiong Wang, Congren Su, Zijian Li, Mingzhu Liu, Xiaoyu Mol Biotechnol Original Paper NKD inhibitor of WNT signaling pathway 2 (NKD2) is an emerging player in cancer onset and progression. Here, it was confirmed that THCA patients have robustly expressed NKD2, which was linked to an advanced pathologic stage. The prognosis was worse for those with high NKD2 levels. Functionally, ectopically produced NKD2 promotes THCA cell proliferation, whereas NKD2 knockdown impairs the ability of THCA cells to proliferate. Mechanically, ectopically expressed NKD2 activated NF-κB transcriptional activity, whereas NKD2-deficient THCA cells showed lower NF-κB transcriptional activity. As a result, NKD2 activates the NF-κB signaling pathway, encouraging the growth of THCA cells. Springer US 2023-02-23 2023 /pmc/articles/PMC10518272/ /pubmed/36820951 http://dx.doi.org/10.1007/s12033-023-00665-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Ke, Shaoying
Pan, Qunxiong
Wang, Congren
Su, Zijian
Li, Mingzhu
Liu, Xiaoyu
NKD2 Trigger NF-κB Signaling Pathway and Facilitates Thyroid Cancer Cell Proliferation
title NKD2 Trigger NF-κB Signaling Pathway and Facilitates Thyroid Cancer Cell Proliferation
title_full NKD2 Trigger NF-κB Signaling Pathway and Facilitates Thyroid Cancer Cell Proliferation
title_fullStr NKD2 Trigger NF-κB Signaling Pathway and Facilitates Thyroid Cancer Cell Proliferation
title_full_unstemmed NKD2 Trigger NF-κB Signaling Pathway and Facilitates Thyroid Cancer Cell Proliferation
title_short NKD2 Trigger NF-κB Signaling Pathway and Facilitates Thyroid Cancer Cell Proliferation
title_sort nkd2 trigger nf-κb signaling pathway and facilitates thyroid cancer cell proliferation
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518272/
https://www.ncbi.nlm.nih.gov/pubmed/36820951
http://dx.doi.org/10.1007/s12033-023-00665-7
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