Model-Guided Design and Optimization of CPA Perfusion Protocols for Whole Organ Cryopreservation

Vitrification could enable long-term organ preservation, but only after loading high-concentration, potentially toxic cryoprotective agents (CPAs) by perfusion. In this paper, we combine a two-compartment Krogh cylinder model with a toxicity cost function to theoretically optimize the loading of CPA...

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Detalles Bibliográficos
Autores principales: Han, Zonghu, Rao, Joseph Sushil, Ramesh, Srivasupradha, Hergesell, Jan, Namsrai, Bat-Erdene, Etheridge, Michael L., Finger, Erik B., Bischof, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518287/
https://www.ncbi.nlm.nih.gov/pubmed/37351756
http://dx.doi.org/10.1007/s10439-023-03255-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518287/
https://www.ncbi.nlm.nih.gov/pubmed/37351756
http://dx.doi.org/10.1007/s10439-023-03255-5

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