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Model-Guided Design and Optimization of CPA Perfusion Protocols for Whole Organ Cryopreservation
Vitrification could enable long-term organ preservation, but only after loading high-concentration, potentially toxic cryoprotective agents (CPAs) by perfusion. In this paper, we combine a two-compartment Krogh cylinder model with a toxicity cost function to theoretically optimize the loading of CPA...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518287/ https://www.ncbi.nlm.nih.gov/pubmed/37351756 http://dx.doi.org/10.1007/s10439-023-03255-5 |