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Anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh

INTRODUCTION: Arsenic methylation converts inorganic arsenic (iAs) to monomethyl (MMA) and dimethyl (DMA) arsenic compounds. Body mass index (BMI) has been positively associated with arsenic methylation efficiency (higher DMA%) in adults, but evidence in pregnancy is inconsistent. We estimated assoc...

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Autores principales: Smith, Tyler J.S., Navas-Acien, Ana, Baker, Sarah, Kok, Caryn, Kruczynski, Kate, Avolio, Lindsay N., Pisanic, Nora, Randad, Pranay R., Fry, Rebecca C., Goessler, Walter, van Geen, Alexander, Buckley, Jessie P., Rahman, Md Hafizur, Ali, Hasmot, Haque, Rezwanul, Shaikh, Saijuddin, Siddiqua, Towfida J., Schulze, Kerry, West, Keith P., Labrique, Alain B., Heaney, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518461/
https://www.ncbi.nlm.nih.gov/pubmed/37343752
http://dx.doi.org/10.1016/j.envres.2023.116453
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author Smith, Tyler J.S.
Navas-Acien, Ana
Baker, Sarah
Kok, Caryn
Kruczynski, Kate
Avolio, Lindsay N.
Pisanic, Nora
Randad, Pranay R.
Fry, Rebecca C.
Goessler, Walter
van Geen, Alexander
Buckley, Jessie P.
Rahman, Md Hafizur
Ali, Hasmot
Haque, Rezwanul
Shaikh, Saijuddin
Siddiqua, Towfida J.
Schulze, Kerry
West, Keith P.
Labrique, Alain B.
Heaney, Christopher D.
author_facet Smith, Tyler J.S.
Navas-Acien, Ana
Baker, Sarah
Kok, Caryn
Kruczynski, Kate
Avolio, Lindsay N.
Pisanic, Nora
Randad, Pranay R.
Fry, Rebecca C.
Goessler, Walter
van Geen, Alexander
Buckley, Jessie P.
Rahman, Md Hafizur
Ali, Hasmot
Haque, Rezwanul
Shaikh, Saijuddin
Siddiqua, Towfida J.
Schulze, Kerry
West, Keith P.
Labrique, Alain B.
Heaney, Christopher D.
author_sort Smith, Tyler J.S.
collection PubMed
description INTRODUCTION: Arsenic methylation converts inorganic arsenic (iAs) to monomethyl (MMA) and dimethyl (DMA) arsenic compounds. Body mass index (BMI) has been positively associated with arsenic methylation efficiency (higher DMA%) in adults, but evidence in pregnancy is inconsistent. We estimated associations between anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh. METHODS: We enrolled pregnant women (n = 784) (median [IQR] gestational week: 14 [13, 15]) in Gaibandha District, Bangladesh from 2018 to 2019. Anthropometric measures were BMI, subscapular and triceps skinfold thicknesses, and mid-upper arm circumference (MUAC), fat area (MUAFA), and muscle area (MUAMA). Arsenic methylation measures were urinary iAs, MMA, and DMA divided by their sum and multiplied by 100 (iAs%, MMA%, and DMA%), primary methylation index (MMA/iAs; PMI), and secondary methylation index (DMA/MMA; SMI). In complete cases (n = 765 [97.6%]), we fitted linear, beta, and Dirichlet regression models to estimate cross-sectional differences in iAs%, MMA%, DMA%, PMI, and SMI per IQR-unit difference in each anthropometric measure, adjusting for drinking water arsenic, age, gestational age, education, living standards index, and plasma folate, vitamin B12, and homocysteine. RESULTS: Median (IQR) BMI, subscapular skinfold thickness, triceps skinfold thickness, MUAC, MUAFA, and MUAMA were 21.5 (19.4, 23.8) kg/m(2), 17.9 (13.2, 24.2) mm, 14.2 (10.2, 18.7) mm, 25.9 (23.8, 28.0) cm, 15.3 (10.5, 20.3) cm(2), and 29.9 (25.6, 34.2) cm(2), respectively. Median (IQR) iAs%, MMA%, DMA%, PMI, and SMI were 12.0 (9.3, 15.2)%, 6.6 (5.3, 8.3)%, 81.0 (77.1, 84.6)%, 0.6 (0.4, 0.7), and 12.2 (9.3, 15.7), respectively. In both unadjusted and adjusted linear models, all anthropometric measures were negatively associated with iAs%, MMA%, and PMI and positively associated with DMA% and SMI. For example, fully adjusted mean differences (95% CI) in DMA% per IQR-unit difference in BMI, subscapular skinfolds thickness, triceps skinfold thickness, MUAC, MUAFA, and MUAMA were 1.72 (1.16, 2.28), 1.58 (0.95, 2.21), 1.74 (1.11, 2.37), 1.45 (0.85, 2.06), 1.70 (1.08, 2.31), and 0.70 (0.13, 1.27) pp, respectively. CONCLUSIONS: Anthropometric measures were positively associated with arsenic methylation efficiency among pregnant women in the early second trimester.
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spelling pubmed-105184612023-10-01 Anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh Smith, Tyler J.S. Navas-Acien, Ana Baker, Sarah Kok, Caryn Kruczynski, Kate Avolio, Lindsay N. Pisanic, Nora Randad, Pranay R. Fry, Rebecca C. Goessler, Walter van Geen, Alexander Buckley, Jessie P. Rahman, Md Hafizur Ali, Hasmot Haque, Rezwanul Shaikh, Saijuddin Siddiqua, Towfida J. Schulze, Kerry West, Keith P. Labrique, Alain B. Heaney, Christopher D. Environ Res Article INTRODUCTION: Arsenic methylation converts inorganic arsenic (iAs) to monomethyl (MMA) and dimethyl (DMA) arsenic compounds. Body mass index (BMI) has been positively associated with arsenic methylation efficiency (higher DMA%) in adults, but evidence in pregnancy is inconsistent. We estimated associations between anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh. METHODS: We enrolled pregnant women (n = 784) (median [IQR] gestational week: 14 [13, 15]) in Gaibandha District, Bangladesh from 2018 to 2019. Anthropometric measures were BMI, subscapular and triceps skinfold thicknesses, and mid-upper arm circumference (MUAC), fat area (MUAFA), and muscle area (MUAMA). Arsenic methylation measures were urinary iAs, MMA, and DMA divided by their sum and multiplied by 100 (iAs%, MMA%, and DMA%), primary methylation index (MMA/iAs; PMI), and secondary methylation index (DMA/MMA; SMI). In complete cases (n = 765 [97.6%]), we fitted linear, beta, and Dirichlet regression models to estimate cross-sectional differences in iAs%, MMA%, DMA%, PMI, and SMI per IQR-unit difference in each anthropometric measure, adjusting for drinking water arsenic, age, gestational age, education, living standards index, and plasma folate, vitamin B12, and homocysteine. RESULTS: Median (IQR) BMI, subscapular skinfold thickness, triceps skinfold thickness, MUAC, MUAFA, and MUAMA were 21.5 (19.4, 23.8) kg/m(2), 17.9 (13.2, 24.2) mm, 14.2 (10.2, 18.7) mm, 25.9 (23.8, 28.0) cm, 15.3 (10.5, 20.3) cm(2), and 29.9 (25.6, 34.2) cm(2), respectively. Median (IQR) iAs%, MMA%, DMA%, PMI, and SMI were 12.0 (9.3, 15.2)%, 6.6 (5.3, 8.3)%, 81.0 (77.1, 84.6)%, 0.6 (0.4, 0.7), and 12.2 (9.3, 15.7), respectively. In both unadjusted and adjusted linear models, all anthropometric measures were negatively associated with iAs%, MMA%, and PMI and positively associated with DMA% and SMI. For example, fully adjusted mean differences (95% CI) in DMA% per IQR-unit difference in BMI, subscapular skinfolds thickness, triceps skinfold thickness, MUAC, MUAFA, and MUAMA were 1.72 (1.16, 2.28), 1.58 (0.95, 2.21), 1.74 (1.11, 2.37), 1.45 (0.85, 2.06), 1.70 (1.08, 2.31), and 0.70 (0.13, 1.27) pp, respectively. CONCLUSIONS: Anthropometric measures were positively associated with arsenic methylation efficiency among pregnant women in the early second trimester. Elsevier 2023-10-01 /pmc/articles/PMC10518461/ /pubmed/37343752 http://dx.doi.org/10.1016/j.envres.2023.116453 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Smith, Tyler J.S.
Navas-Acien, Ana
Baker, Sarah
Kok, Caryn
Kruczynski, Kate
Avolio, Lindsay N.
Pisanic, Nora
Randad, Pranay R.
Fry, Rebecca C.
Goessler, Walter
van Geen, Alexander
Buckley, Jessie P.
Rahman, Md Hafizur
Ali, Hasmot
Haque, Rezwanul
Shaikh, Saijuddin
Siddiqua, Towfida J.
Schulze, Kerry
West, Keith P.
Labrique, Alain B.
Heaney, Christopher D.
Anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh
title Anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh
title_full Anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh
title_fullStr Anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh
title_full_unstemmed Anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh
title_short Anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh
title_sort anthropometric measures and arsenic methylation among pregnant women in rural northern bangladesh
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518461/
https://www.ncbi.nlm.nih.gov/pubmed/37343752
http://dx.doi.org/10.1016/j.envres.2023.116453
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