Cargando…

The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset

A fetal pituitary hormone, oxytocin which causes uterine contractions, increases throughout gestation, and its increase reaches 10-fold from week 32 afterward. Oxytocin is, on the other hand, degraded by placental leucine aminopeptidase (P-LAP) which exists in both terminal villi and maternal blood....

Descripción completa

Detalles Bibliográficos
Autores principales: Yoshihara, Masato, Mizutani, Shigehiko, Matsumoto, Kunio, Kato, Yukio, Masuo, Yusuke, Harumasa, Arita, Iyoshi, Shohei, Tano, Sho, Mizutani, Hidesuke, Kotani, Tomomi, Mizutani, Eita, Shibata, Kiyosumi, Kajiyama, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518509/
https://www.ncbi.nlm.nih.gov/pubmed/37753515
http://dx.doi.org/10.1016/j.eurox.2023.100210
_version_ 1785109529878331392
author Yoshihara, Masato
Mizutani, Shigehiko
Matsumoto, Kunio
Kato, Yukio
Masuo, Yusuke
Harumasa, Arita
Iyoshi, Shohei
Tano, Sho
Mizutani, Hidesuke
Kotani, Tomomi
Mizutani, Eita
Shibata, Kiyosumi
Kajiyama, Hiroaki
author_facet Yoshihara, Masato
Mizutani, Shigehiko
Matsumoto, Kunio
Kato, Yukio
Masuo, Yusuke
Harumasa, Arita
Iyoshi, Shohei
Tano, Sho
Mizutani, Hidesuke
Kotani, Tomomi
Mizutani, Eita
Shibata, Kiyosumi
Kajiyama, Hiroaki
author_sort Yoshihara, Masato
collection PubMed
description A fetal pituitary hormone, oxytocin which causes uterine contractions, increases throughout gestation, and its increase reaches 10-fold from week 32 afterward. Oxytocin is, on the other hand, degraded by placental leucine aminopeptidase (P-LAP) which exists in both terminal villi and maternal blood. Maternal blood P-LAP increases with advancing gestation under the control of non-genomic effects of progesterone, which is also produced from the placenta. Progesterone is converted to estrogen by CYP17A1 localized in the fetal adrenal gland and placenta at term. The higher oxytocin concentrations in the fetus than in the mother demonstrate not only fetal oxytocin production but also its degradation and/or inhibition of leakage from fetus to mother by P-LAP. Until labor onset, the pregnant uterus is quiescent possibly due to the balance between increasing fetal oxytocin and P-LAP under control of progesterone. A close correlation exists between the feto-placental and maternal units in the placental circulation, although the blood in the two circulations does not necessarily mix. Fetal maturation results in progesterone withdrawal via the CYP17A1 activation accompanied with fetal oxytocin increase. Contribution of fetal oxytocin to labor onset has been acknowledged through the recognition that the effect of fetal oxytocin in the maternal blood is strictly regulated by its degradation by P-LAP under the control of non-genomic effects of progesterone. In all senses, the fetus necessarily takes the initiative in labor onset.
format Online
Article
Text
id pubmed-10518509
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-105185092023-09-26 The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset Yoshihara, Masato Mizutani, Shigehiko Matsumoto, Kunio Kato, Yukio Masuo, Yusuke Harumasa, Arita Iyoshi, Shohei Tano, Sho Mizutani, Hidesuke Kotani, Tomomi Mizutani, Eita Shibata, Kiyosumi Kajiyama, Hiroaki Eur J Obstet Gynecol Reprod Biol X Review A fetal pituitary hormone, oxytocin which causes uterine contractions, increases throughout gestation, and its increase reaches 10-fold from week 32 afterward. Oxytocin is, on the other hand, degraded by placental leucine aminopeptidase (P-LAP) which exists in both terminal villi and maternal blood. Maternal blood P-LAP increases with advancing gestation under the control of non-genomic effects of progesterone, which is also produced from the placenta. Progesterone is converted to estrogen by CYP17A1 localized in the fetal adrenal gland and placenta at term. The higher oxytocin concentrations in the fetus than in the mother demonstrate not only fetal oxytocin production but also its degradation and/or inhibition of leakage from fetus to mother by P-LAP. Until labor onset, the pregnant uterus is quiescent possibly due to the balance between increasing fetal oxytocin and P-LAP under control of progesterone. A close correlation exists between the feto-placental and maternal units in the placental circulation, although the blood in the two circulations does not necessarily mix. Fetal maturation results in progesterone withdrawal via the CYP17A1 activation accompanied with fetal oxytocin increase. Contribution of fetal oxytocin to labor onset has been acknowledged through the recognition that the effect of fetal oxytocin in the maternal blood is strictly regulated by its degradation by P-LAP under the control of non-genomic effects of progesterone. In all senses, the fetus necessarily takes the initiative in labor onset. Elsevier 2023-06-21 /pmc/articles/PMC10518509/ /pubmed/37753515 http://dx.doi.org/10.1016/j.eurox.2023.100210 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yoshihara, Masato
Mizutani, Shigehiko
Matsumoto, Kunio
Kato, Yukio
Masuo, Yusuke
Harumasa, Arita
Iyoshi, Shohei
Tano, Sho
Mizutani, Hidesuke
Kotani, Tomomi
Mizutani, Eita
Shibata, Kiyosumi
Kajiyama, Hiroaki
The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset
title The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset
title_full The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset
title_fullStr The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset
title_full_unstemmed The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset
title_short The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset
title_sort balance between fetal oxytocin and placental leucine aminopeptidase (p-lap) controls human uterine contraction around labor onset
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518509/
https://www.ncbi.nlm.nih.gov/pubmed/37753515
http://dx.doi.org/10.1016/j.eurox.2023.100210
work_keys_str_mv AT yoshiharamasato thebalancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT mizutanishigehiko thebalancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT matsumotokunio thebalancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT katoyukio thebalancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT masuoyusuke thebalancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT harumasaarita thebalancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT iyoshishohei thebalancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT tanosho thebalancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT mizutanihidesuke thebalancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT kotanitomomi thebalancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT mizutanieita thebalancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT shibatakiyosumi thebalancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT kajiyamahiroaki thebalancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT yoshiharamasato balancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT mizutanishigehiko balancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT matsumotokunio balancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT katoyukio balancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT masuoyusuke balancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT harumasaarita balancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT iyoshishohei balancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT tanosho balancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT mizutanihidesuke balancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT kotanitomomi balancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT mizutanieita balancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT shibatakiyosumi balancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset
AT kajiyamahiroaki balancebetweenfetaloxytocinandplacentalleucineaminopeptidaseplapcontrolshumanuterinecontractionaroundlaboronset