Hyperammonemia Due to Empyema

A 91-year-old woman was brought to our hospital with altered consciousness. Blood tests showed an increased ammonia level of 468 μg/dL and a normal liver function. Chest computed tomography showed massive right pleural effusion with loculation. We immediately performed chest drainage using two drain...

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Detalles Bibliográficos
Autores principales: Wada, Hiroshi, Goto, Miyuki, Misonou, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518550/
https://www.ncbi.nlm.nih.gov/pubmed/36725045
http://dx.doi.org/10.2169/internalmedicine.0922-22
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author Wada, Hiroshi
Goto, Miyuki
Misonou, Masashi
author_facet Wada, Hiroshi
Goto, Miyuki
Misonou, Masashi
author_sort Wada, Hiroshi
collection PubMed
description A 91-year-old woman was brought to our hospital with altered consciousness. Blood tests showed an increased ammonia level of 468 μg/dL and a normal liver function. Chest computed tomography showed massive right pleural effusion with loculation. We immediately performed chest drainage using two drainage tubes. The pleural effusate pH was 8.5. We diagnosed her with right empyema leading to hyperammonemia and initiated ampicillin/sulbactam therapy. However, she developed progressive renal failure and died on the third day. Empyema caused by urease-producing bacteria can lead to hyperammonemia. This is the first report of hyperammonemia due to empyema in the English literature.
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spelling pubmed-105185502023-09-26 Hyperammonemia Due to Empyema Wada, Hiroshi Goto, Miyuki Misonou, Masashi Intern Med Case Report A 91-year-old woman was brought to our hospital with altered consciousness. Blood tests showed an increased ammonia level of 468 μg/dL and a normal liver function. Chest computed tomography showed massive right pleural effusion with loculation. We immediately performed chest drainage using two drainage tubes. The pleural effusate pH was 8.5. We diagnosed her with right empyema leading to hyperammonemia and initiated ampicillin/sulbactam therapy. However, she developed progressive renal failure and died on the third day. Empyema caused by urease-producing bacteria can lead to hyperammonemia. This is the first report of hyperammonemia due to empyema in the English literature. The Japanese Society of Internal Medicine 2023-02-01 2023-09-01 /pmc/articles/PMC10518550/ /pubmed/36725045 http://dx.doi.org/10.2169/internalmedicine.0922-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Wada, Hiroshi
Goto, Miyuki
Misonou, Masashi
Hyperammonemia Due to Empyema
title Hyperammonemia Due to Empyema
title_full Hyperammonemia Due to Empyema
title_fullStr Hyperammonemia Due to Empyema
title_full_unstemmed Hyperammonemia Due to Empyema
title_short Hyperammonemia Due to Empyema
title_sort hyperammonemia due to empyema
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518550/
https://www.ncbi.nlm.nih.gov/pubmed/36725045
http://dx.doi.org/10.2169/internalmedicine.0922-22
work_keys_str_mv AT wadahiroshi hyperammonemiaduetoempyema
AT gotomiyuki hyperammonemiaduetoempyema
AT misonoumasashi hyperammonemiaduetoempyema

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