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Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy
Lymphoproliferative disorders and Epstein-Barr virus reactivation (EBV-LPDs) have various forms of onset, ranging from infectious mononucleosis-like syndrome (IM-like) to lymphoma, although whether or not IM-like progresses to lymphoma remains unclear. A 61-year-old man was diagnosed with aplastic a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518559/ https://www.ncbi.nlm.nih.gov/pubmed/36725050 http://dx.doi.org/10.2169/internalmedicine.0539-22 |
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author | Kawarada, Yo Hara, Ryujiro Kitahara, Toshihiko Numata, Hiroki Watanabe, Shigeki Yamada, Masatoshi Ando, Kiyoshi |
author_facet | Kawarada, Yo Hara, Ryujiro Kitahara, Toshihiko Numata, Hiroki Watanabe, Shigeki Yamada, Masatoshi Ando, Kiyoshi |
author_sort | Kawarada, Yo |
collection | PubMed |
description | Lymphoproliferative disorders and Epstein-Barr virus reactivation (EBV-LPDs) have various forms of onset, ranging from infectious mononucleosis-like syndrome (IM-like) to lymphoma, although whether or not IM-like progresses to lymphoma remains unclear. A 61-year-old man was diagnosed with aplastic anemia (AA). Polyclonal atypical B-lymphocytes were observed in the peripheral blood, and IM-like was diagnosed. Atypical lymphocytes disappeared, but a gastrointestinal examination revealed diffuse large B-cell lymphoma (DLBCL). Rituximab was initiated but later discontinued because of severe acute respiratory syndrome coronavirus 2 infection. Pancytopenia due to AA exacerbation recurred. The patient ultimately died of multiple organ failure due to bacterial infection. |
format | Online Article Text |
id | pubmed-10518559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-105185592023-09-26 Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy Kawarada, Yo Hara, Ryujiro Kitahara, Toshihiko Numata, Hiroki Watanabe, Shigeki Yamada, Masatoshi Ando, Kiyoshi Intern Med Case Report Lymphoproliferative disorders and Epstein-Barr virus reactivation (EBV-LPDs) have various forms of onset, ranging from infectious mononucleosis-like syndrome (IM-like) to lymphoma, although whether or not IM-like progresses to lymphoma remains unclear. A 61-year-old man was diagnosed with aplastic anemia (AA). Polyclonal atypical B-lymphocytes were observed in the peripheral blood, and IM-like was diagnosed. Atypical lymphocytes disappeared, but a gastrointestinal examination revealed diffuse large B-cell lymphoma (DLBCL). Rituximab was initiated but later discontinued because of severe acute respiratory syndrome coronavirus 2 infection. Pancytopenia due to AA exacerbation recurred. The patient ultimately died of multiple organ failure due to bacterial infection. The Japanese Society of Internal Medicine 2023-02-01 2023-09-01 /pmc/articles/PMC10518559/ /pubmed/36725050 http://dx.doi.org/10.2169/internalmedicine.0539-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Kawarada, Yo Hara, Ryujiro Kitahara, Toshihiko Numata, Hiroki Watanabe, Shigeki Yamada, Masatoshi Ando, Kiyoshi Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy |
title | Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy |
title_full | Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy |
title_fullStr | Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy |
title_full_unstemmed | Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy |
title_short | Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy |
title_sort | aplastic anemia with epstein-barr virus reactivation after anti-thymocyte globulin therapy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518559/ https://www.ncbi.nlm.nih.gov/pubmed/36725050 http://dx.doi.org/10.2169/internalmedicine.0539-22 |
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