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Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy

Lymphoproliferative disorders and Epstein-Barr virus reactivation (EBV-LPDs) have various forms of onset, ranging from infectious mononucleosis-like syndrome (IM-like) to lymphoma, although whether or not IM-like progresses to lymphoma remains unclear. A 61-year-old man was diagnosed with aplastic a...

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Autores principales: Kawarada, Yo, Hara, Ryujiro, Kitahara, Toshihiko, Numata, Hiroki, Watanabe, Shigeki, Yamada, Masatoshi, Ando, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518559/
https://www.ncbi.nlm.nih.gov/pubmed/36725050
http://dx.doi.org/10.2169/internalmedicine.0539-22
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author Kawarada, Yo
Hara, Ryujiro
Kitahara, Toshihiko
Numata, Hiroki
Watanabe, Shigeki
Yamada, Masatoshi
Ando, Kiyoshi
author_facet Kawarada, Yo
Hara, Ryujiro
Kitahara, Toshihiko
Numata, Hiroki
Watanabe, Shigeki
Yamada, Masatoshi
Ando, Kiyoshi
author_sort Kawarada, Yo
collection PubMed
description Lymphoproliferative disorders and Epstein-Barr virus reactivation (EBV-LPDs) have various forms of onset, ranging from infectious mononucleosis-like syndrome (IM-like) to lymphoma, although whether or not IM-like progresses to lymphoma remains unclear. A 61-year-old man was diagnosed with aplastic anemia (AA). Polyclonal atypical B-lymphocytes were observed in the peripheral blood, and IM-like was diagnosed. Atypical lymphocytes disappeared, but a gastrointestinal examination revealed diffuse large B-cell lymphoma (DLBCL). Rituximab was initiated but later discontinued because of severe acute respiratory syndrome coronavirus 2 infection. Pancytopenia due to AA exacerbation recurred. The patient ultimately died of multiple organ failure due to bacterial infection.
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spelling pubmed-105185592023-09-26 Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy Kawarada, Yo Hara, Ryujiro Kitahara, Toshihiko Numata, Hiroki Watanabe, Shigeki Yamada, Masatoshi Ando, Kiyoshi Intern Med Case Report Lymphoproliferative disorders and Epstein-Barr virus reactivation (EBV-LPDs) have various forms of onset, ranging from infectious mononucleosis-like syndrome (IM-like) to lymphoma, although whether or not IM-like progresses to lymphoma remains unclear. A 61-year-old man was diagnosed with aplastic anemia (AA). Polyclonal atypical B-lymphocytes were observed in the peripheral blood, and IM-like was diagnosed. Atypical lymphocytes disappeared, but a gastrointestinal examination revealed diffuse large B-cell lymphoma (DLBCL). Rituximab was initiated but later discontinued because of severe acute respiratory syndrome coronavirus 2 infection. Pancytopenia due to AA exacerbation recurred. The patient ultimately died of multiple organ failure due to bacterial infection. The Japanese Society of Internal Medicine 2023-02-01 2023-09-01 /pmc/articles/PMC10518559/ /pubmed/36725050 http://dx.doi.org/10.2169/internalmedicine.0539-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kawarada, Yo
Hara, Ryujiro
Kitahara, Toshihiko
Numata, Hiroki
Watanabe, Shigeki
Yamada, Masatoshi
Ando, Kiyoshi
Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy
title Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy
title_full Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy
title_fullStr Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy
title_full_unstemmed Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy
title_short Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy
title_sort aplastic anemia with epstein-barr virus reactivation after anti-thymocyte globulin therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518559/
https://www.ncbi.nlm.nih.gov/pubmed/36725050
http://dx.doi.org/10.2169/internalmedicine.0539-22
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