Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy

Tumor-derived extracellular vesicles (EVs) have been associated with immune evasion and tumor progression. We show that the RNA-sensing receptor RIG-I within tumor cells governs biogenesis and immunomodulatory function of EVs. Cancer-intrinsic RIG-I activation releases EVs, which mediate dendritic c...

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Detalles Bibliográficos
Autores principales: Heidegger, Simon, Stritzke, Florian, Dahl, Sarah, Daßler-Plenker, Juliane, Joachim, Laura, Buschmann, Dominik, Fan, Kaiji, Sauer, Carolin M., Ludwig, Nils, Winter, Christof, Enssle, Stefan, Li, Suqi, Perl, Markus, Görgens, André, Haas, Tobias, Orberg, Erik Thiele, Göttert, Sascha, Wölfel, Catherine, Engleitner, Thomas, Cortés-Ciriano, Isidro, Rad, Roland, Herr, Wolfgang, Giebel, Bernd, Ruland, Jürgen, Bassermann, Florian, Coch, Christoph, Hartmann, Gunther, Poeck, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518594/
https://www.ncbi.nlm.nih.gov/pubmed/37657445
http://dx.doi.org/10.1016/j.xcrm.2023.101171

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