CYP19A1 mediates severe SARS-CoV-2 disease outcome in males

Male sex represents one of the major risk factors for severe COVID-19 outcome. However, underlying mechanisms that mediate sex-dependent disease outcome are as yet unknown. Here, we identify the CYP19A1 gene encoding for the testosterone-to-estradiol metabolizing enzyme CYP19A1 (also known as aromat...

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Autores principales: Stanelle-Bertram, Stephanie, Beck, Sebastian, Mounogou, Nancy Kouassi, Schaumburg, Berfin, Stoll, Fabian, Al Jawazneh, Amirah, Schmal, Zoé, Bai, Tian, Zickler, Martin, Beythien, Georg, Becker, Kathrin, de la Roi, Madeleine, Heinrich, Fabian, Schulz, Claudia, Sauter, Martina, Krasemann, Susanne, Lange, Philine, Heinemann, Axel, van Riel, Debby, Leijten, Lonneke, Bauer, Lisa, van den Bosch, Thierry P.P., Lopuhaä, Boaz, Busche, Tobias, Wibberg, Daniel, Schaudien, Dirk, Goldmann, Torsten, Lüttjohann, Anna, Ruschinski, Jenny, Jania, Hanna, Müller, Zacharias, Pinho dos Reis, Vinicius, Krupp-Buzimkic, Vanessa, Wolff, Martin, Fallerini, Chiara, Baldassarri, Margherita, Furini, Simone, Norwood, Katrina, Käufer, Christopher, Schützenmeister, Nina, von Köckritz-Blickwede, Maren, Schroeder, Maria, Jarczak, Dominik, Nierhaus, Axel, Welte, Tobias, Kluge, Stefan, McHardy, Alice C., Sommer, Frank, Kalinowski, Jörn, Krauss-Etschmann, Susanne, Richter, Franziska, von der Thüsen, Jan, Baumgärtner, Wolfgang, Klingel, Karin, Ondruschka, Benjamin, Renieri, Alessandra, Gabriel, Gülsah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518605/
https://www.ncbi.nlm.nih.gov/pubmed/37572667
http://dx.doi.org/10.1016/j.xcrm.2023.101152

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