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Heterologous DNA-prime/protein-boost immunization with a monomeric SARS-CoV-2 spike antigen redundantizes the trimeric receptor-binding domain structure to induce neutralizing antibodies in old mice

A multitude of alterations in the old immune system impair its functional integrity. Closely related, older individuals show, for example, a reduced responsiveness to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines. However, systematic strategies to specifically improve the eff...

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Detalles Bibliográficos
Autores principales:	Pflumm, Dominik, Seidel, Alina, Klein, Fabrice, Groß, Rüdiger, Krutzke, Lea, Kochanek, Stefan, Kroschel, Joris, Münch, Jan, Stifter, Katja, Schirmbeck, Reinhold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518615/ https://www.ncbi.nlm.nih.gov/pubmed/37753087 http://dx.doi.org/10.3389/fimmu.2023.1231274

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