CCHFV vaccine development, current challenges, limitations, and future directions

Crimean-Congo hemorrhagic fever (CCHF) is the most prevalent tick-borne viral disease affecting humans. The disease is life-threatening in many regions of the developing world, including Africa, Asia, the Middle East, and Southern Europe. In line with the rapidly increasing disease prevalence, vario...

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Autores principales: Ahata, Büşra, Akçapınar, Günseli Bayram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518622/
https://www.ncbi.nlm.nih.gov/pubmed/37753088
http://dx.doi.org/10.3389/fimmu.2023.1238882
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author Ahata, Büşra
Akçapınar, Günseli Bayram
author_facet Ahata, Büşra
Akçapınar, Günseli Bayram
author_sort Ahata, Büşra
collection PubMed
description Crimean-Congo hemorrhagic fever (CCHF) is the most prevalent tick-borne viral disease affecting humans. The disease is life-threatening in many regions of the developing world, including Africa, Asia, the Middle East, and Southern Europe. In line with the rapidly increasing disease prevalence, various vaccine strategies are under development. Despite a large number of potential vaccine candidates, there are no approved vaccines as of yet. This paper presents a detailed comparative analysis of current efforts to develop vaccines against CCHFV, limitations associated with current efforts, and future research directions.
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spelling pubmed-105186222023-09-26 CCHFV vaccine development, current challenges, limitations, and future directions Ahata, Büşra Akçapınar, Günseli Bayram Front Immunol Immunology Crimean-Congo hemorrhagic fever (CCHF) is the most prevalent tick-borne viral disease affecting humans. The disease is life-threatening in many regions of the developing world, including Africa, Asia, the Middle East, and Southern Europe. In line with the rapidly increasing disease prevalence, various vaccine strategies are under development. Despite a large number of potential vaccine candidates, there are no approved vaccines as of yet. This paper presents a detailed comparative analysis of current efforts to develop vaccines against CCHFV, limitations associated with current efforts, and future research directions. Frontiers Media S.A. 2023-09-11 /pmc/articles/PMC10518622/ /pubmed/37753088 http://dx.doi.org/10.3389/fimmu.2023.1238882 Text en Copyright © 2023 Ahata and Akçapınar https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ahata, Büşra
Akçapınar, Günseli Bayram
CCHFV vaccine development, current challenges, limitations, and future directions
title CCHFV vaccine development, current challenges, limitations, and future directions
title_full CCHFV vaccine development, current challenges, limitations, and future directions
title_fullStr CCHFV vaccine development, current challenges, limitations, and future directions
title_full_unstemmed CCHFV vaccine development, current challenges, limitations, and future directions
title_short CCHFV vaccine development, current challenges, limitations, and future directions
title_sort cchfv vaccine development, current challenges, limitations, and future directions
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518622/
https://www.ncbi.nlm.nih.gov/pubmed/37753088
http://dx.doi.org/10.3389/fimmu.2023.1238882
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