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Targeting intracellular galectins for cancer treatment
Although considerable attention has been paid to the role of extracellular galectins in modulating, positively or negatively, tumor growth and metastasis, we have witnessed a growing interest in the role of intracellular galectins in response to their environment. This is not surprising as many gale...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518623/ https://www.ncbi.nlm.nih.gov/pubmed/37753083 http://dx.doi.org/10.3389/fimmu.2023.1269391 |
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author | Nehmé, Rita St-Pierre, Yves |
author_facet | Nehmé, Rita St-Pierre, Yves |
author_sort | Nehmé, Rita |
collection | PubMed |
description | Although considerable attention has been paid to the role of extracellular galectins in modulating, positively or negatively, tumor growth and metastasis, we have witnessed a growing interest in the role of intracellular galectins in response to their environment. This is not surprising as many galectins preferentially exist in cytosolic and nuclear compartments, which is consistent with the fact that they are exported outside the cells via a yet undefined non-classical mechanism. This review summarizes our most recent knowledge of their intracellular functions in cancer cells and provides some directions for future strategies to inhibit their role in cancer progression. |
format | Online Article Text |
id | pubmed-10518623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105186232023-09-26 Targeting intracellular galectins for cancer treatment Nehmé, Rita St-Pierre, Yves Front Immunol Immunology Although considerable attention has been paid to the role of extracellular galectins in modulating, positively or negatively, tumor growth and metastasis, we have witnessed a growing interest in the role of intracellular galectins in response to their environment. This is not surprising as many galectins preferentially exist in cytosolic and nuclear compartments, which is consistent with the fact that they are exported outside the cells via a yet undefined non-classical mechanism. This review summarizes our most recent knowledge of their intracellular functions in cancer cells and provides some directions for future strategies to inhibit their role in cancer progression. Frontiers Media S.A. 2023-09-11 /pmc/articles/PMC10518623/ /pubmed/37753083 http://dx.doi.org/10.3389/fimmu.2023.1269391 Text en Copyright © 2023 Nehmé and St-Pierre https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Nehmé, Rita St-Pierre, Yves Targeting intracellular galectins for cancer treatment |
title | Targeting intracellular galectins for cancer treatment |
title_full | Targeting intracellular galectins for cancer treatment |
title_fullStr | Targeting intracellular galectins for cancer treatment |
title_full_unstemmed | Targeting intracellular galectins for cancer treatment |
title_short | Targeting intracellular galectins for cancer treatment |
title_sort | targeting intracellular galectins for cancer treatment |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518623/ https://www.ncbi.nlm.nih.gov/pubmed/37753083 http://dx.doi.org/10.3389/fimmu.2023.1269391 |
work_keys_str_mv | AT nehmerita targetingintracellulargalectinsforcancertreatment AT stpierreyves targetingintracellulargalectinsforcancertreatment |