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Targeting intracellular galectins for cancer treatment

Although considerable attention has been paid to the role of extracellular galectins in modulating, positively or negatively, tumor growth and metastasis, we have witnessed a growing interest in the role of intracellular galectins in response to their environment. This is not surprising as many gale...

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Detalles Bibliográficos
Autores principales: Nehmé, Rita, St-Pierre, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518623/
https://www.ncbi.nlm.nih.gov/pubmed/37753083
http://dx.doi.org/10.3389/fimmu.2023.1269391
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author Nehmé, Rita
St-Pierre, Yves
author_facet Nehmé, Rita
St-Pierre, Yves
author_sort Nehmé, Rita
collection PubMed
description Although considerable attention has been paid to the role of extracellular galectins in modulating, positively or negatively, tumor growth and metastasis, we have witnessed a growing interest in the role of intracellular galectins in response to their environment. This is not surprising as many galectins preferentially exist in cytosolic and nuclear compartments, which is consistent with the fact that they are exported outside the cells via a yet undefined non-classical mechanism. This review summarizes our most recent knowledge of their intracellular functions in cancer cells and provides some directions for future strategies to inhibit their role in cancer progression.
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spelling pubmed-105186232023-09-26 Targeting intracellular galectins for cancer treatment Nehmé, Rita St-Pierre, Yves Front Immunol Immunology Although considerable attention has been paid to the role of extracellular galectins in modulating, positively or negatively, tumor growth and metastasis, we have witnessed a growing interest in the role of intracellular galectins in response to their environment. This is not surprising as many galectins preferentially exist in cytosolic and nuclear compartments, which is consistent with the fact that they are exported outside the cells via a yet undefined non-classical mechanism. This review summarizes our most recent knowledge of their intracellular functions in cancer cells and provides some directions for future strategies to inhibit their role in cancer progression. Frontiers Media S.A. 2023-09-11 /pmc/articles/PMC10518623/ /pubmed/37753083 http://dx.doi.org/10.3389/fimmu.2023.1269391 Text en Copyright © 2023 Nehmé and St-Pierre https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Nehmé, Rita
St-Pierre, Yves
Targeting intracellular galectins for cancer treatment
title Targeting intracellular galectins for cancer treatment
title_full Targeting intracellular galectins for cancer treatment
title_fullStr Targeting intracellular galectins for cancer treatment
title_full_unstemmed Targeting intracellular galectins for cancer treatment
title_short Targeting intracellular galectins for cancer treatment
title_sort targeting intracellular galectins for cancer treatment
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518623/
https://www.ncbi.nlm.nih.gov/pubmed/37753083
http://dx.doi.org/10.3389/fimmu.2023.1269391
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