Spatially aware deep learning reveals tumor heterogeneity patterns that encode distinct kidney cancer states

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Clear cell renal cell carcinoma (ccRCC) is molecularly heterogeneous, immune infiltrated, and selectively sensitive to immune checkpoint inhibition (ICI). However, the joint tumor-immune states that mediate ICI response remain elusive. We develop spatially aware deep-learning models of tumor and imm...

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Detalles Bibliográficos
Autores principales: Nyman, Jackson, Denize, Thomas, Bakouny, Ziad, Labaki, Chris, Titchen, Breanna M., Bi, Kevin, Hari, Surya Narayanan, Rosenthal, Jacob, Mehta, Nicita, Jiang, Bowen, Sharma, Bijaya, Felt, Kristen, Umeton, Renato, Braun, David A., Rodig, Scott, Choueiri, Toni K., Signoretti, Sabina, Van Allen, Eliezer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518628/
https://www.ncbi.nlm.nih.gov/pubmed/37729872
http://dx.doi.org/10.1016/j.xcrm.2023.101189
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