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High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor

The long-term clinical outcomes of severe obesity due to leptin signaling deficiency are unknown. We carry out a retrospective cross-sectional investigation of a large cohort of children with leptin (LEP), LEP receptor (LEPR), or melanocortin 4 receptor (MC4R) deficiency (n = 145) to evaluate the pr...

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Detalles Bibliográficos
Autores principales:	Saeed, Sadia, Khanam, Roohia, Janjua, Qasim M., Manzoor, Jaida, Ning, Lijiao, Hanook, Sharoon, Canouil, Mickaël, Ali, Muhammad, Ayesha, Hina, Khan, Waqas I., Farooqi, I. Sadaf, Yeo, Giles S.H., O'Rahilly, Stephen, Bonnefond, Amélie, Butt, Taeed A., Arslan, Muhammad, Froguel, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518629/ https://www.ncbi.nlm.nih.gov/pubmed/37659411 http://dx.doi.org/10.1016/j.xcrm.2023.101187

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