Venetoclax, alone and in combination with the BH3 mimetic S63845, depletes HIV-1 latently infected cells and delays rebound in humanized mice

HIV-1 persists indefinitely in people living with HIV (PLWH) on antiretroviral therapy (ART). If ART is stopped, the virus rapidly rebounds from long-lived latently infected cells. Using a humanized mouse model of HIV-1 infection and CD4(+) T cells from PLWH on ART, we investigate whether antagonizi...

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Detalles Bibliográficos
Autores principales: Arandjelovic, Philip, Kim, Youry, Cooney, James P., Preston, Simon P., Doerflinger, Marcel, McMahon, James H., Garner, Sarah E., Zerbato, Jennifer M., Roche, Michael, Tumpach, Carolin, Ong, Jesslyn, Sheerin, Dylan, Smyth, Gordon K., Anderson, Jenny L., Allison, Cody C., Lewin, Sharon R., Pellegrini, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518630/
https://www.ncbi.nlm.nih.gov/pubmed/37652018
http://dx.doi.org/10.1016/j.xcrm.2023.101178

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