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PARP-1 improves leukemia outcomes by inducing parthanatos during chemotherapy

Previous chemotherapy research has focused almost exclusively on apoptosis. Here, a standard frontline drug combination of cytarabine and idarubicin induces distinct features of caspase-independent, poly(ADP-ribose) polymerase 1 (PARP-1)-mediated programmed cell death “parthanatos” in acute myeloid...

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Detalles Bibliográficos
Autores principales:	Maru, Bruktawit, Messikommer, Alessandra, Huang, Linhui, Seipel, Katja, Kovecses, Olivia, Valk, Peter J.M., Theocharides, Alexandre P.A., Mercier, Francois E., Pabst, Thomas, McKeague, Maureen, Luedtke, Nathan W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518631/ https://www.ncbi.nlm.nih.gov/pubmed/37683650 http://dx.doi.org/10.1016/j.xcrm.2023.101191

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