Cargando…
Reduced PDE4D7 in prostate cancer correlates with genomic downregulation within the upstream PDE4D coding region
AIM: PDE4D7 expression is significantly associated with prostate cancer (PCa) progression, representing an attractive prognostic biomarker. We sought to determine whether other genes in the PDE4D coding region were associated. PATIENTS & METHODS: RNA from biopsy punch samples of resected tumor t...
Autores principales: | Gulliver, Chloe, Baillie, George S, Hoffmann, Ralf |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Science Ltd
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518809/ https://www.ncbi.nlm.nih.gov/pubmed/37752916 http://dx.doi.org/10.2144/fsoa-2023-0064 |
Ejemplares similares
-
The CAPRA&PDE4D5/7/9 Prognostic Model Is Significantly Associated with Adverse Post-Surgical Pathology Outcomes
por: Gulliver, Chloe, et al.
Publicado: (2022) -
Loss of PDE4D7 expression promotes androgen independence, neuroendocrine differentiation and alterations in DNA repair: implications for therapeutic strategies
por: Gulliver, Chloe, et al.
Publicado: (2023) -
The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus
por: Byrne, Ashleigh M., et al.
Publicado: (2015) -
The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells
por: Henderson, D J P, et al.
Publicado: (2014) -
PDE4D and PDE4B Function in Distinct Subcellular Compartments in Mouse Embryonic Fibroblasts
por: Blackman, Brigitte E., et al.
Publicado: (2011)