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Adjustable Fluorescence Emission of J-Aggregated Tricarbocyanine in the Near-Infrared-II Region
[Image: see text] Near-infrared (NIR) J-aggregates attract increasing attention in many areas, especially in biomedical applications, as they combine the advantages of NIR spectroscopy with the unique J-aggregation properties of organic dyes. They enhance light absorption and have been used as effec...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518818/ https://www.ncbi.nlm.nih.gov/pubmed/37682586 http://dx.doi.org/10.1021/acs.jpcb.3c04554 |
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author | Dar, Nitzan Weissman, Haim Ankri, Rinat |
author_facet | Dar, Nitzan Weissman, Haim Ankri, Rinat |
author_sort | Dar, Nitzan |
collection | PubMed |
description | [Image: see text] Near-infrared (NIR) J-aggregates attract increasing attention in many areas, especially in biomedical applications, as they combine the advantages of NIR spectroscopy with the unique J-aggregation properties of organic dyes. They enhance light absorption and have been used as effective biological imaging and therapeutic agents to achieve high-resolution imaging or effective phototherapy in vivo. In this work, we present novel J-aggregates composed of the well-known cyanine molecules. Cyanines are one of the few types of molecules whose absorption and emission can be shifted over a broad spectral range, from the ultraviolet (UV) to the NIR regime. They can easily transform into J-aggregates with narrow absorption and emission peaks, which is accompanied by a red shift in their spectra. In this work, we show, for the first time, that the tricarbocyanine dye (IR 820) has two sharp fluorescence emission bands in the NIR-II region with high photostability. These emission bands can be tuned to a desired wavelength in the range of 1150–1560 and 1675 nm, with a linear dependence on the excitation wavelength. Cryogenic transmission electron microscopy (cryo-TEM) images are presented, and combined with molecular modeling analysis, they confirm IR 820 π-stacked self-assembled fibrous structures. |
format | Online Article Text |
id | pubmed-10518818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-105188182023-09-26 Adjustable Fluorescence Emission of J-Aggregated Tricarbocyanine in the Near-Infrared-II Region Dar, Nitzan Weissman, Haim Ankri, Rinat J Phys Chem B [Image: see text] Near-infrared (NIR) J-aggregates attract increasing attention in many areas, especially in biomedical applications, as they combine the advantages of NIR spectroscopy with the unique J-aggregation properties of organic dyes. They enhance light absorption and have been used as effective biological imaging and therapeutic agents to achieve high-resolution imaging or effective phototherapy in vivo. In this work, we present novel J-aggregates composed of the well-known cyanine molecules. Cyanines are one of the few types of molecules whose absorption and emission can be shifted over a broad spectral range, from the ultraviolet (UV) to the NIR regime. They can easily transform into J-aggregates with narrow absorption and emission peaks, which is accompanied by a red shift in their spectra. In this work, we show, for the first time, that the tricarbocyanine dye (IR 820) has two sharp fluorescence emission bands in the NIR-II region with high photostability. These emission bands can be tuned to a desired wavelength in the range of 1150–1560 and 1675 nm, with a linear dependence on the excitation wavelength. Cryogenic transmission electron microscopy (cryo-TEM) images are presented, and combined with molecular modeling analysis, they confirm IR 820 π-stacked self-assembled fibrous structures. American Chemical Society 2023-09-08 /pmc/articles/PMC10518818/ /pubmed/37682586 http://dx.doi.org/10.1021/acs.jpcb.3c04554 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Dar, Nitzan Weissman, Haim Ankri, Rinat Adjustable Fluorescence Emission of J-Aggregated Tricarbocyanine in the Near-Infrared-II Region |
title | Adjustable Fluorescence
Emission of J-Aggregated
Tricarbocyanine in the Near-Infrared-II Region |
title_full | Adjustable Fluorescence
Emission of J-Aggregated
Tricarbocyanine in the Near-Infrared-II Region |
title_fullStr | Adjustable Fluorescence
Emission of J-Aggregated
Tricarbocyanine in the Near-Infrared-II Region |
title_full_unstemmed | Adjustable Fluorescence
Emission of J-Aggregated
Tricarbocyanine in the Near-Infrared-II Region |
title_short | Adjustable Fluorescence
Emission of J-Aggregated
Tricarbocyanine in the Near-Infrared-II Region |
title_sort | adjustable fluorescence
emission of j-aggregated
tricarbocyanine in the near-infrared-ii region |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518818/ https://www.ncbi.nlm.nih.gov/pubmed/37682586 http://dx.doi.org/10.1021/acs.jpcb.3c04554 |
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