Investigation of microbial coinfection in 453 septic COVID-19 patients admitted to hospital; a retrospective study

AIM: We evaluated the rate of COVID-19 microbial coinfection in an Iranian population. METHODS: In this single-center, retrospective observational study, we evaluated 453 septic COVID-19 patients for possible coinfection in an Iranian hospital. RESULTS: Overall, 211 (46.57%) cases died due to COVID-...

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Detalles Bibliográficos
Autores principales: Khavandegar, Armin, Siami, Zeinab, Goudarzi, Sogand, Rasooli, Aziz, Ettehad, Yeganeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518821/
https://www.ncbi.nlm.nih.gov/pubmed/37752919
http://dx.doi.org/10.2144/fsoa-2023-0066
Descripción
Sumario:AIM: We evaluated the rate of COVID-19 microbial coinfection in an Iranian population. METHODS: In this single-center, retrospective observational study, we evaluated 453 septic COVID-19 patients for possible coinfection in an Iranian hospital. RESULTS: Overall, 211 (46.57%) cases died due to COVID-19 complications. Positive respiratory secretion and blood cultures were reported in 99 (21.9%) and 19 (4.2%) cases. Klebsiella species were the most commonly isolated microorganisms in respiratory (n = 50, 50.5%) and blood (n = 10, 52.6%) specimens. After adjustment for underlying disorders, positive respiratory microbial cultures significantly increase the odds of developing death, intubation, and ICU admission and negatively impact healthy discharge (P < 0.05). CONCLUSION: Coinfections with bacteria and fungi independently contribute to poor outcomes in septic COVID-19 patients.

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