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β1-adrenergic receptor polymorphisms: a possible genetic predictor of bisoprolol response in acute coronary syndrome
AIM: To investigate the association between beta1-adrenergic receptor (ADRB1) polymorphisms and response to bisoprolol treatment in beta-blocker naive patients with acute coronary syndrome (ACS). PATIENTS & METHODS: Seventy-seven patients received bisoprolol for four weeks. Blood pressure and he...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Science Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518825/ https://www.ncbi.nlm.nih.gov/pubmed/37753361 http://dx.doi.org/10.2144/fsoa-2023-0113 |
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author | Fayed, Mohamed S Saleh, Mohamed Ayman Sabri, Nagwa A Elkholy, Amal A |
author_facet | Fayed, Mohamed S Saleh, Mohamed Ayman Sabri, Nagwa A Elkholy, Amal A |
author_sort | Fayed, Mohamed S |
collection | PubMed |
description | AIM: To investigate the association between beta1-adrenergic receptor (ADRB1) polymorphisms and response to bisoprolol treatment in beta-blocker naive patients with acute coronary syndrome (ACS). PATIENTS & METHODS: Seventy-seven patients received bisoprolol for four weeks. Blood pressure and heart rate were measured at baseline and during treatment. TaqMan allelic discrimination method was utilized for ADRB1 Ser49Gly and Arg389Gly genotyping. RESULTS: Arg389Arg carriers showed greater reductions in systolic and diastolic blood pressure (-8.5% ± 7.8% vs -0.76% ± 8.7%, p = 0.000218), and (-9.5% ± 9.7% vs -0.80% ± 11.5%, p = 0.000149), respectively, compared with Gly389 carriers. No statistical difference was found for study's outcomes based on codon 49. CONCLUSION: Arg389Gly polymorphism is a promising bisoprolol response predictor in ACS patients. |
format | Online Article Text |
id | pubmed-10518825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Future Science Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-105188252023-09-26 β1-adrenergic receptor polymorphisms: a possible genetic predictor of bisoprolol response in acute coronary syndrome Fayed, Mohamed S Saleh, Mohamed Ayman Sabri, Nagwa A Elkholy, Amal A Future Sci OA Research Article AIM: To investigate the association between beta1-adrenergic receptor (ADRB1) polymorphisms and response to bisoprolol treatment in beta-blocker naive patients with acute coronary syndrome (ACS). PATIENTS & METHODS: Seventy-seven patients received bisoprolol for four weeks. Blood pressure and heart rate were measured at baseline and during treatment. TaqMan allelic discrimination method was utilized for ADRB1 Ser49Gly and Arg389Gly genotyping. RESULTS: Arg389Arg carriers showed greater reductions in systolic and diastolic blood pressure (-8.5% ± 7.8% vs -0.76% ± 8.7%, p = 0.000218), and (-9.5% ± 9.7% vs -0.80% ± 11.5%, p = 0.000149), respectively, compared with Gly389 carriers. No statistical difference was found for study's outcomes based on codon 49. CONCLUSION: Arg389Gly polymorphism is a promising bisoprolol response predictor in ACS patients. Future Science Ltd 2023-08-22 /pmc/articles/PMC10518825/ /pubmed/37753361 http://dx.doi.org/10.2144/fsoa-2023-0113 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Research Article Fayed, Mohamed S Saleh, Mohamed Ayman Sabri, Nagwa A Elkholy, Amal A β1-adrenergic receptor polymorphisms: a possible genetic predictor of bisoprolol response in acute coronary syndrome |
title | β1-adrenergic receptor polymorphisms: a possible genetic predictor of bisoprolol response in acute coronary syndrome |
title_full | β1-adrenergic receptor polymorphisms: a possible genetic predictor of bisoprolol response in acute coronary syndrome |
title_fullStr | β1-adrenergic receptor polymorphisms: a possible genetic predictor of bisoprolol response in acute coronary syndrome |
title_full_unstemmed | β1-adrenergic receptor polymorphisms: a possible genetic predictor of bisoprolol response in acute coronary syndrome |
title_short | β1-adrenergic receptor polymorphisms: a possible genetic predictor of bisoprolol response in acute coronary syndrome |
title_sort | β1-adrenergic receptor polymorphisms: a possible genetic predictor of bisoprolol response in acute coronary syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518825/ https://www.ncbi.nlm.nih.gov/pubmed/37753361 http://dx.doi.org/10.2144/fsoa-2023-0113 |
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