Defective quality control autophagy in Hyperhomocysteinemia promotes ER stress and consequent neuronal apoptosis through proteotoxicity

Homocysteine (Hcy), produced physiologically in all cells, is an intermediate metabolite of methionine and cysteine metabolism. Hyperhomocysteinemia (HHcy) resulting from an in-born error of metabolism that leads to accumulation of high levels of Hcy, is associated with vascular damage, neurodegener...

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Detalles Bibliográficos
Autores principales: Kaur, Bhavneet, Sharma, Pradeep Kumar, Chatterjee, Barun, Bissa, Bhawana, Nattarayan, Vasugi, Ramasamy, Soundhar, Bhat, Ajay, Lal, Megha, Samaddar, Sarbani, Banerjee, Sourav, Roy, Soumya Sinha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518934/
https://www.ncbi.nlm.nih.gov/pubmed/37749555
http://dx.doi.org/10.1186/s12964-023-01288-w

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