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Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer
In 2021, breast cancer accounted for a substantial proportion of cancer cases and represented the second leading cause of cancer deaths among women worldwide. Although tumor cells originate from normal cells in the human body, they possess distinct biological characteristics resulting from changes i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518937/ https://www.ncbi.nlm.nih.gov/pubmed/37749560 http://dx.doi.org/10.1186/s13020-023-00822-9 |
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author | Jiang, Rui-yuan Fang, Zi-ru Zhang, Huan-ping Xu, Jun-yao Zhu, Jia-yu Chen, Ke-yu Wang, Wei Jiang, Xiao Wang, Xiao-jia |
author_facet | Jiang, Rui-yuan Fang, Zi-ru Zhang, Huan-ping Xu, Jun-yao Zhu, Jia-yu Chen, Ke-yu Wang, Wei Jiang, Xiao Wang, Xiao-jia |
author_sort | Jiang, Rui-yuan |
collection | PubMed |
description | In 2021, breast cancer accounted for a substantial proportion of cancer cases and represented the second leading cause of cancer deaths among women worldwide. Although tumor cells originate from normal cells in the human body, they possess distinct biological characteristics resulting from changes in gene structure and function of cancer cells in contrast with normal cells. These distinguishing features, known as hallmarks of cancer cells, differ from those of normal cells. The hallmarks primarily include high metabolic activity, mitochondrial dysfunction, and resistance to cell death. Current evidence suggests that the fundamental hallmarks of tumor cells affect the tissue structure, function, and metabolism of tumor cells and their internal and external environment. Therefore, these fundamental hallmarks of tumor cells enable tumor cells to proliferate, invade and avoid apoptosis. Modifying these hallmarks of tumor cells represents a new and potentially promising approach to tumor treatment. The key to breast cancer treatment lies in identifying the optimal therapeutic agent with minimal toxicity to normal cells, considering the specific types of tumor cells in patients. Some herbal medicines contain active ingredients which can precisely achieve this purpose. In this review, we introduce Ginsenoside's mechanism and research significance in achieving the therapeutic effect of breast cancer by changing the functional hallmarks of tumor cells, providing a new perspective for the potential application of Ginsenoside as a therapeutic drug for breast cancer. |
format | Online Article Text |
id | pubmed-10518937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105189372023-09-26 Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer Jiang, Rui-yuan Fang, Zi-ru Zhang, Huan-ping Xu, Jun-yao Zhu, Jia-yu Chen, Ke-yu Wang, Wei Jiang, Xiao Wang, Xiao-jia Chin Med Review In 2021, breast cancer accounted for a substantial proportion of cancer cases and represented the second leading cause of cancer deaths among women worldwide. Although tumor cells originate from normal cells in the human body, they possess distinct biological characteristics resulting from changes in gene structure and function of cancer cells in contrast with normal cells. These distinguishing features, known as hallmarks of cancer cells, differ from those of normal cells. The hallmarks primarily include high metabolic activity, mitochondrial dysfunction, and resistance to cell death. Current evidence suggests that the fundamental hallmarks of tumor cells affect the tissue structure, function, and metabolism of tumor cells and their internal and external environment. Therefore, these fundamental hallmarks of tumor cells enable tumor cells to proliferate, invade and avoid apoptosis. Modifying these hallmarks of tumor cells represents a new and potentially promising approach to tumor treatment. The key to breast cancer treatment lies in identifying the optimal therapeutic agent with minimal toxicity to normal cells, considering the specific types of tumor cells in patients. Some herbal medicines contain active ingredients which can precisely achieve this purpose. In this review, we introduce Ginsenoside's mechanism and research significance in achieving the therapeutic effect of breast cancer by changing the functional hallmarks of tumor cells, providing a new perspective for the potential application of Ginsenoside as a therapeutic drug for breast cancer. BioMed Central 2023-09-25 /pmc/articles/PMC10518937/ /pubmed/37749560 http://dx.doi.org/10.1186/s13020-023-00822-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Jiang, Rui-yuan Fang, Zi-ru Zhang, Huan-ping Xu, Jun-yao Zhu, Jia-yu Chen, Ke-yu Wang, Wei Jiang, Xiao Wang, Xiao-jia Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer |
title | Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer |
title_full | Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer |
title_fullStr | Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer |
title_full_unstemmed | Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer |
title_short | Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer |
title_sort | ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518937/ https://www.ncbi.nlm.nih.gov/pubmed/37749560 http://dx.doi.org/10.1186/s13020-023-00822-9 |
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