LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration

BACKGROUND: G protein-coupled receptor heteromerization is believed to exert dynamic regulatory impact on signal transduction. CXC chemokine receptor 4 (CXCR4) and its ligand CXCL12, both of which are overexpressed in many cancers, play a pivotal role in metastasis. Likewise, lysophosphatidic acid r...

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Detalles Bibliográficos
Autores principales: Hong, Jong Min, Lee, Jin-Woo, Seen, Dong-Seung, Jeong, Jae-Yeon, Huh, Won-Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518940/
https://www.ncbi.nlm.nih.gov/pubmed/37749552
http://dx.doi.org/10.1186/s12964-023-01261-7

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