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ACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization
BACKGROUND: Multitarget tyrosine kinase inhibitors (mTKIs) such as Regorafenib and Sorafenib have already been approved for the treatment of many solid tumours. However, the efficacy of mTKIs in colorectal cancer (CRC) is limited; the underlined mechanism remains largely elusive. Our study was aimed...
Autores principales: | Lu, Xiaolin, Liu, Ruiqi, Liao, Yuanyu, Cui, Luying, Sun, Haoxiu, Zhang, Dongzhi, Wang, Bojun, Fang, Lin, Guan, Xin, Yao, Yuanfei, Liu, Chao, Zhang, Yanqiao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518977/ https://www.ncbi.nlm.nih.gov/pubmed/37743483 http://dx.doi.org/10.1186/s12916-023-03066-4 |
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