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Advances in biological functions and applications of apoptotic vesicles
BACKGROUND: Apoptotic vesicles are extracellular vesicles generated by apoptotic cells that were previously regarded as containing waste or harmful substances but are now thought to play an important role in signal transduction and homeostasis regulation. METHODS: In the present review, we reviewed...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519056/ https://www.ncbi.nlm.nih.gov/pubmed/37749626 http://dx.doi.org/10.1186/s12964-023-01251-9 |
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author | Zou, Xianghui Lei, Qian Luo, Xinghong Yin, Jingyao chen, Shuoling Hao, Chunbo Shiyu, Liu Ma, Dandan |
author_facet | Zou, Xianghui Lei, Qian Luo, Xinghong Yin, Jingyao chen, Shuoling Hao, Chunbo Shiyu, Liu Ma, Dandan |
author_sort | Zou, Xianghui |
collection | PubMed |
description | BACKGROUND: Apoptotic vesicles are extracellular vesicles generated by apoptotic cells that were previously regarded as containing waste or harmful substances but are now thought to play an important role in signal transduction and homeostasis regulation. METHODS: In the present review, we reviewed many articles published over the past decades on the subtypes and formation of apoptotic vesicles and the existing applications of these vesicles. RESULTS: Apoptotic bodies were once regarded as vesicles released by apoptotic cells, however, apoptotic vesicles are now regarded to include apoptotic bodies, apoptotic microvesicles and apoptotic exosomes, which exhibit variation in terms of biogenesis, sizes and properties. Applications of apoptotic vesicles were first reported long ago, but such reports have been rarer than those of other extracellular vesicles. At present, apoptotic vesicles have been utilized mainly in four aspects, including in direct therapeutic applications, in their engineering as carriers, in their construction as vaccines and in their utilization in diagnosis. CONCLUSION: Building on a deeper understanding of their composition and characteristics, some studies have utilized apoptotic vesicles to treat diseases in more novel ways. However, their limitations for clinical translation, such as heterogeneity, have also emerged. In general, apoptotic vesicles have great application potential, but there are still many barriers to overcome in their investigation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01251-9. |
format | Online Article Text |
id | pubmed-10519056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105190562023-09-26 Advances in biological functions and applications of apoptotic vesicles Zou, Xianghui Lei, Qian Luo, Xinghong Yin, Jingyao chen, Shuoling Hao, Chunbo Shiyu, Liu Ma, Dandan Cell Commun Signal Review BACKGROUND: Apoptotic vesicles are extracellular vesicles generated by apoptotic cells that were previously regarded as containing waste or harmful substances but are now thought to play an important role in signal transduction and homeostasis regulation. METHODS: In the present review, we reviewed many articles published over the past decades on the subtypes and formation of apoptotic vesicles and the existing applications of these vesicles. RESULTS: Apoptotic bodies were once regarded as vesicles released by apoptotic cells, however, apoptotic vesicles are now regarded to include apoptotic bodies, apoptotic microvesicles and apoptotic exosomes, which exhibit variation in terms of biogenesis, sizes and properties. Applications of apoptotic vesicles were first reported long ago, but such reports have been rarer than those of other extracellular vesicles. At present, apoptotic vesicles have been utilized mainly in four aspects, including in direct therapeutic applications, in their engineering as carriers, in their construction as vaccines and in their utilization in diagnosis. CONCLUSION: Building on a deeper understanding of their composition and characteristics, some studies have utilized apoptotic vesicles to treat diseases in more novel ways. However, their limitations for clinical translation, such as heterogeneity, have also emerged. In general, apoptotic vesicles have great application potential, but there are still many barriers to overcome in their investigation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01251-9. BioMed Central 2023-09-25 /pmc/articles/PMC10519056/ /pubmed/37749626 http://dx.doi.org/10.1186/s12964-023-01251-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Zou, Xianghui Lei, Qian Luo, Xinghong Yin, Jingyao chen, Shuoling Hao, Chunbo Shiyu, Liu Ma, Dandan Advances in biological functions and applications of apoptotic vesicles |
title | Advances in biological functions and applications of apoptotic vesicles |
title_full | Advances in biological functions and applications of apoptotic vesicles |
title_fullStr | Advances in biological functions and applications of apoptotic vesicles |
title_full_unstemmed | Advances in biological functions and applications of apoptotic vesicles |
title_short | Advances in biological functions and applications of apoptotic vesicles |
title_sort | advances in biological functions and applications of apoptotic vesicles |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519056/ https://www.ncbi.nlm.nih.gov/pubmed/37749626 http://dx.doi.org/10.1186/s12964-023-01251-9 |
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