CHSY1 promotes CD8(+) T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening

BACKGROUND: The most common site of metastasis in colorectal cancer (CRC) is the liver and liver metastases occur in more than 50% of patients during diagnosis or treatment. The occurrence of metastasis depends on a series of events known as the invasive-metastasis cascade. Currently, the underlying...

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Detalles Bibliográficos
Autores principales: Sun, Guangshun, Zhao, Siqi, Fan, Zhongguo, Wang, Yuliang, Liu, Hanyuan, Cao, Hengsong, Sun, Guoqiang, Huang, Tian, Cai, Hongzhou, Pan, Hong, Rong, Dawei, Gao, Yun, Tang, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519095/
https://www.ncbi.nlm.nih.gov/pubmed/37749638
http://dx.doi.org/10.1186/s13046-023-02803-0

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