Cargando…

Reducing Risk Factors for Necrotizing Enterocolitis: What Is the Recent Evidence and Biologic Plausibility Supporting Probiotics?

BACKGROUND: Development of necrotizing enterocolitis is multifactorial, with contributing factors that are unique to the preterm infant in the neonatal intensive care unit (NICU). The use of probiotics may reduce these risk factors. PURPOSE: To evaluate evidence of biologic plausibility for probioti...

Descripción completa

Detalles Bibliográficos
Autores principales: Dickison, Linda, Gonzalez-Shalaby, Carmela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519298/
https://www.ncbi.nlm.nih.gov/pubmed/35446273
http://dx.doi.org/10.1097/ANC.0000000000000983
_version_ 1785109675482546176
author Dickison, Linda
Gonzalez-Shalaby, Carmela
author_facet Dickison, Linda
Gonzalez-Shalaby, Carmela
author_sort Dickison, Linda
collection PubMed
description BACKGROUND: Development of necrotizing enterocolitis is multifactorial, with contributing factors that are unique to the preterm infant in the neonatal intensive care unit (NICU). The use of probiotics may reduce these risk factors. PURPOSE: To evaluate evidence of biologic plausibility for probiotic supplementation to mitigate key risk factors implicated in the development of disease and show recent evidence of safety and effectiveness. DATA SOURCES: A literature survey of electronic databases, including PubMed, Cochrane Database of Systematic Reviews, and CINAHL, was conducted. STUDY SELECTION: Selection terms included “necrotizing enterocolitis,” “probiotics,” and “prematurity.” Reviews that were included were full text, in English, and published in the last 5 years. Ten systematic reviews of randomized controlled trials were extracted from 749 records. Excluded were studies that used adjuncts to probiotics, such as lactoferrin or prebiotics, and studies of probiotics given antenatally. DATA EXTRACTION: Two independent reviewers extracted data to AMSTAR 2, a critical appraisal tool for systematic reviews of randomized or nonrandomized studies of healthcare interventions. RESULTS: All the reviews found statistically significant reductions in necrotizing enterocolitis rates after supplementation with probiotics. None of the reviews reported adverse effects. IMPLICATION FOR PRACTICE AND RESEARCH: Probiotic supplementation with specific strains reduces risk for necrotizing enterocolitis. To advance probiotic use in the NICU, additional high-quality trials are needed to focus on specific strains or combinations of strains and to evaluate dosing and duration of treatment. Video Abstract available athttps://journals.lww.com/advancesinneonatalcare/Pages/videogallery.aspx.
format Online
Article
Text
id pubmed-10519298
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Wolters Kluwer Health, Inc.
record_format MEDLINE/PubMed
spelling pubmed-105192982023-09-26 Reducing Risk Factors for Necrotizing Enterocolitis: What Is the Recent Evidence and Biologic Plausibility Supporting Probiotics? Dickison, Linda Gonzalez-Shalaby, Carmela Adv Neonatal Care Neonatal Evidence Based Reviews BACKGROUND: Development of necrotizing enterocolitis is multifactorial, with contributing factors that are unique to the preterm infant in the neonatal intensive care unit (NICU). The use of probiotics may reduce these risk factors. PURPOSE: To evaluate evidence of biologic plausibility for probiotic supplementation to mitigate key risk factors implicated in the development of disease and show recent evidence of safety and effectiveness. DATA SOURCES: A literature survey of electronic databases, including PubMed, Cochrane Database of Systematic Reviews, and CINAHL, was conducted. STUDY SELECTION: Selection terms included “necrotizing enterocolitis,” “probiotics,” and “prematurity.” Reviews that were included were full text, in English, and published in the last 5 years. Ten systematic reviews of randomized controlled trials were extracted from 749 records. Excluded were studies that used adjuncts to probiotics, such as lactoferrin or prebiotics, and studies of probiotics given antenatally. DATA EXTRACTION: Two independent reviewers extracted data to AMSTAR 2, a critical appraisal tool for systematic reviews of randomized or nonrandomized studies of healthcare interventions. RESULTS: All the reviews found statistically significant reductions in necrotizing enterocolitis rates after supplementation with probiotics. None of the reviews reported adverse effects. IMPLICATION FOR PRACTICE AND RESEARCH: Probiotic supplementation with specific strains reduces risk for necrotizing enterocolitis. To advance probiotic use in the NICU, additional high-quality trials are needed to focus on specific strains or combinations of strains and to evaluate dosing and duration of treatment. Video Abstract available athttps://journals.lww.com/advancesinneonatalcare/Pages/videogallery.aspx. Wolters Kluwer Health, Inc. 2022-12 2022-04-21 /pmc/articles/PMC10519298/ /pubmed/35446273 http://dx.doi.org/10.1097/ANC.0000000000000983 Text en © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the National Association of Neonatal Nurses https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Neonatal Evidence Based Reviews
Dickison, Linda
Gonzalez-Shalaby, Carmela
Reducing Risk Factors for Necrotizing Enterocolitis: What Is the Recent Evidence and Biologic Plausibility Supporting Probiotics?
title Reducing Risk Factors for Necrotizing Enterocolitis: What Is the Recent Evidence and Biologic Plausibility Supporting Probiotics?
title_full Reducing Risk Factors for Necrotizing Enterocolitis: What Is the Recent Evidence and Biologic Plausibility Supporting Probiotics?
title_fullStr Reducing Risk Factors for Necrotizing Enterocolitis: What Is the Recent Evidence and Biologic Plausibility Supporting Probiotics?
title_full_unstemmed Reducing Risk Factors for Necrotizing Enterocolitis: What Is the Recent Evidence and Biologic Plausibility Supporting Probiotics?
title_short Reducing Risk Factors for Necrotizing Enterocolitis: What Is the Recent Evidence and Biologic Plausibility Supporting Probiotics?
title_sort reducing risk factors for necrotizing enterocolitis: what is the recent evidence and biologic plausibility supporting probiotics?
topic Neonatal Evidence Based Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519298/
https://www.ncbi.nlm.nih.gov/pubmed/35446273
http://dx.doi.org/10.1097/ANC.0000000000000983
work_keys_str_mv AT dickisonlinda reducingriskfactorsfornecrotizingenterocolitiswhatistherecentevidenceandbiologicplausibilitysupportingprobiotics
AT gonzalezshalabycarmela reducingriskfactorsfornecrotizingenterocolitiswhatistherecentevidenceandbiologicplausibilitysupportingprobiotics