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Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates

Soluble aggregates are reported to be the most neurotoxic species of α-Synuclein (αSyn) in Parkinson’s disease (PD) and hence are a promising target for diagnosis and treatment of PD. However, the predominantly intracellular location of αSyn limits its accessibility, especially for antibody-based mo...

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Detalles Bibliográficos
Autores principales:	Petersen, Inga, Ali, Muhammad Ilyas, Petrovic, Alex, Ytterberg, Anders Jimmy, Staxäng, Karin, Hodik, Monika, Rofo, Fadi, Bondza, Sina, Hultqvist, Greta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519360/ https://www.ncbi.nlm.nih.gov/pubmed/37737124 http://dx.doi.org/10.1080/19420862.2023.2256668

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