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Course and clinical severity of the SARS-CoV-2 Omicron variant infection in Tianjin, China

There is limited information describing the course and severity of illness in subjects infected by the severe acute respiratory syndrome coronavirus 2 Omicron variant, especially in children. In this population-based cohort study, subjects with Omicron variant infection during the outbreak between J...

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Autores principales: Ren, Yi, Shi, Lixia, Xie, Yi, Wang, Chao, Zhang, Wenxin, Wang, Feifei, Sun, Haibai, Huang, Lijun, Wu, Yuanrong, Xing, Zhiheng, Ren, Wenjuan, Heinrich, Joachim, Wu, Qi, Pei, Zhengcun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519499/
https://www.ncbi.nlm.nih.gov/pubmed/37746953
http://dx.doi.org/10.1097/MD.0000000000034669
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author Ren, Yi
Shi, Lixia
Xie, Yi
Wang, Chao
Zhang, Wenxin
Wang, Feifei
Sun, Haibai
Huang, Lijun
Wu, Yuanrong
Xing, Zhiheng
Ren, Wenjuan
Heinrich, Joachim
Wu, Qi
Pei, Zhengcun
author_facet Ren, Yi
Shi, Lixia
Xie, Yi
Wang, Chao
Zhang, Wenxin
Wang, Feifei
Sun, Haibai
Huang, Lijun
Wu, Yuanrong
Xing, Zhiheng
Ren, Wenjuan
Heinrich, Joachim
Wu, Qi
Pei, Zhengcun
author_sort Ren, Yi
collection PubMed
description There is limited information describing the course and severity of illness in subjects infected by the severe acute respiratory syndrome coronavirus 2 Omicron variant, especially in children. In this population-based cohort study, subjects with Omicron variant infection during the outbreak between January 8 and February 12, 2022 in Tianjin, China were included (n = 429). The main outcomes were the distribution of asymptomatic, mild, moderate, and severe patients, and clinical courses including the interval from positive polymerase chain reaction (PCR) test to the onset, aggravation or relief of symptoms, and the interval of reversing positive PCR-test into negative, and length of hospital stay. Of the 429 subjects (113 [26.3%] children; 239 [55.7%] female; median age, 36 years [interquartile range 15.0 to 55.0 years]), the proportion (95% CI) of symptomatic subjects on admission was 95.6% (93.2%, 97.2%), including 60.4% (55.7%, 64.9%) mild, 35.0% (30.6%, 39.6%) moderate, and 0.2% (0.0%, 1.3%) severe. Compared with adults, children had lower proportion of moderate Covid-19 (8.8% vs 44.3%). On discharge, 45.9% (41.3%, 50.7%) and 42.2% (37.6%, 46.9%) of the subjects were diagnosed as having experienced mild and moderate Covid-19. The median (interquartile range) length of hospital stay was 14.0 (12.0, 15.0) days. The median interval of reversing positive PCR-test into negative was 12.0 (10.0, 13.0) days. Symptomatic and moderate Covid-19 in Omicron infections was common in adults and children, recovery from Omicron infections took around 2 weeks of time. The severe acute respiratory syndrome coronavirus 2 Omicron infection in this study was not as mild as previously suggested.
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spelling pubmed-105194992023-09-26 Course and clinical severity of the SARS-CoV-2 Omicron variant infection in Tianjin, China Ren, Yi Shi, Lixia Xie, Yi Wang, Chao Zhang, Wenxin Wang, Feifei Sun, Haibai Huang, Lijun Wu, Yuanrong Xing, Zhiheng Ren, Wenjuan Heinrich, Joachim Wu, Qi Pei, Zhengcun Medicine (Baltimore) 4400 There is limited information describing the course and severity of illness in subjects infected by the severe acute respiratory syndrome coronavirus 2 Omicron variant, especially in children. In this population-based cohort study, subjects with Omicron variant infection during the outbreak between January 8 and February 12, 2022 in Tianjin, China were included (n = 429). The main outcomes were the distribution of asymptomatic, mild, moderate, and severe patients, and clinical courses including the interval from positive polymerase chain reaction (PCR) test to the onset, aggravation or relief of symptoms, and the interval of reversing positive PCR-test into negative, and length of hospital stay. Of the 429 subjects (113 [26.3%] children; 239 [55.7%] female; median age, 36 years [interquartile range 15.0 to 55.0 years]), the proportion (95% CI) of symptomatic subjects on admission was 95.6% (93.2%, 97.2%), including 60.4% (55.7%, 64.9%) mild, 35.0% (30.6%, 39.6%) moderate, and 0.2% (0.0%, 1.3%) severe. Compared with adults, children had lower proportion of moderate Covid-19 (8.8% vs 44.3%). On discharge, 45.9% (41.3%, 50.7%) and 42.2% (37.6%, 46.9%) of the subjects were diagnosed as having experienced mild and moderate Covid-19. The median (interquartile range) length of hospital stay was 14.0 (12.0, 15.0) days. The median interval of reversing positive PCR-test into negative was 12.0 (10.0, 13.0) days. Symptomatic and moderate Covid-19 in Omicron infections was common in adults and children, recovery from Omicron infections took around 2 weeks of time. The severe acute respiratory syndrome coronavirus 2 Omicron infection in this study was not as mild as previously suggested. Lippincott Williams & Wilkins 2023-09-22 /pmc/articles/PMC10519499/ /pubmed/37746953 http://dx.doi.org/10.1097/MD.0000000000034669 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 4400
Ren, Yi
Shi, Lixia
Xie, Yi
Wang, Chao
Zhang, Wenxin
Wang, Feifei
Sun, Haibai
Huang, Lijun
Wu, Yuanrong
Xing, Zhiheng
Ren, Wenjuan
Heinrich, Joachim
Wu, Qi
Pei, Zhengcun
Course and clinical severity of the SARS-CoV-2 Omicron variant infection in Tianjin, China
title Course and clinical severity of the SARS-CoV-2 Omicron variant infection in Tianjin, China
title_full Course and clinical severity of the SARS-CoV-2 Omicron variant infection in Tianjin, China
title_fullStr Course and clinical severity of the SARS-CoV-2 Omicron variant infection in Tianjin, China
title_full_unstemmed Course and clinical severity of the SARS-CoV-2 Omicron variant infection in Tianjin, China
title_short Course and clinical severity of the SARS-CoV-2 Omicron variant infection in Tianjin, China
title_sort course and clinical severity of the sars-cov-2 omicron variant infection in tianjin, china
topic 4400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519499/
https://www.ncbi.nlm.nih.gov/pubmed/37746953
http://dx.doi.org/10.1097/MD.0000000000034669
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