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The relationship between serum pro-B type natriuretic peptide level and bone mineral density in peritoneal dialysis patients

We aimed to evaluate the relationship between serum N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) and lumbar bone mineral density (BMD) in peritoneal dialysis (PD) patients. Fasting blood samples were obtained from 46 PD patients. BMD was measured by dual-energy X-ray absorptiometry of the...

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Autores principales: Doğan, Ayse Gulsen, Uzeli, Ulkem, Eser, Baris, Dogan, Murat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519546/
https://www.ncbi.nlm.nih.gov/pubmed/37746986
http://dx.doi.org/10.1097/MD.0000000000034666
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author Doğan, Ayse Gulsen
Uzeli, Ulkem
Eser, Baris
Dogan, Murat
author_facet Doğan, Ayse Gulsen
Uzeli, Ulkem
Eser, Baris
Dogan, Murat
author_sort Doğan, Ayse Gulsen
collection PubMed
description We aimed to evaluate the relationship between serum N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) and lumbar bone mineral density (BMD) in peritoneal dialysis (PD) patients. Fasting blood samples were obtained from 46 PD patients. BMD was measured by dual-energy X-ray absorptiometry of the lumbar vertebrae (L1–L4). Circulating serum NT-pro-BNP levels were measured using commercial kits compatible with the Roche Cobas e 601 immunoassay device. Forty-six patients were included in our study. Increased age, low body mass index (BMI), and high-serum NT-pro-BNP are significantly associated with decreased BMD. The results show a statistically positive correlation between lumbar T-score values and BMI (r = 0.456; P = .001), while lumbar T-score values and PTH (rho = -0.336; P = .022) and log-NT-pro-BNP. There is a statistically negative correlation between BNP (rho = -0.355; P = .015). The lumbar T-score value decreases by 0.800 units when log-NT-pro-BNP increases by 1 unit and increases by 0.323 units when BMI increases by 1 unit. The established model is statistically significant (F = 6.190; P < .001). Our study in PD patients showed that serum NT-pro-BNP level was negatively correlated and BMI was positively correlated with lumbar BMD.
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spelling pubmed-105195462023-09-26 The relationship between serum pro-B type natriuretic peptide level and bone mineral density in peritoneal dialysis patients Doğan, Ayse Gulsen Uzeli, Ulkem Eser, Baris Dogan, Murat Medicine (Baltimore) 5200 We aimed to evaluate the relationship between serum N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) and lumbar bone mineral density (BMD) in peritoneal dialysis (PD) patients. Fasting blood samples were obtained from 46 PD patients. BMD was measured by dual-energy X-ray absorptiometry of the lumbar vertebrae (L1–L4). Circulating serum NT-pro-BNP levels were measured using commercial kits compatible with the Roche Cobas e 601 immunoassay device. Forty-six patients were included in our study. Increased age, low body mass index (BMI), and high-serum NT-pro-BNP are significantly associated with decreased BMD. The results show a statistically positive correlation between lumbar T-score values and BMI (r = 0.456; P = .001), while lumbar T-score values and PTH (rho = -0.336; P = .022) and log-NT-pro-BNP. There is a statistically negative correlation between BNP (rho = -0.355; P = .015). The lumbar T-score value decreases by 0.800 units when log-NT-pro-BNP increases by 1 unit and increases by 0.323 units when BMI increases by 1 unit. The established model is statistically significant (F = 6.190; P < .001). Our study in PD patients showed that serum NT-pro-BNP level was negatively correlated and BMI was positively correlated with lumbar BMD. Lippincott Williams & Wilkins 2023-09-22 /pmc/articles/PMC10519546/ /pubmed/37746986 http://dx.doi.org/10.1097/MD.0000000000034666 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5200
Doğan, Ayse Gulsen
Uzeli, Ulkem
Eser, Baris
Dogan, Murat
The relationship between serum pro-B type natriuretic peptide level and bone mineral density in peritoneal dialysis patients
title The relationship between serum pro-B type natriuretic peptide level and bone mineral density in peritoneal dialysis patients
title_full The relationship between serum pro-B type natriuretic peptide level and bone mineral density in peritoneal dialysis patients
title_fullStr The relationship between serum pro-B type natriuretic peptide level and bone mineral density in peritoneal dialysis patients
title_full_unstemmed The relationship between serum pro-B type natriuretic peptide level and bone mineral density in peritoneal dialysis patients
title_short The relationship between serum pro-B type natriuretic peptide level and bone mineral density in peritoneal dialysis patients
title_sort relationship between serum pro-b type natriuretic peptide level and bone mineral density in peritoneal dialysis patients
topic 5200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519546/
https://www.ncbi.nlm.nih.gov/pubmed/37746986
http://dx.doi.org/10.1097/MD.0000000000034666
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