Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis

Impaired spermatogenesis and male infertility are common manifestations associated with mitochondrial diseases, yet the underlying mechanisms linking these conditions remain elusive. In this study, we demonstrate that mice deficient for the mitochondrial intra-membrane rhomboid protease PARL, a rece...

Descripción completa

Detalles Bibliográficos
Autores principales: Radaelli, Enrico, Assenmacher, Charles-Antoine, Verrelle, Jillian, Banerjee, Esha, Manero, Florence, Khiati, Salim, Girona, Anais, Lopez-Lluch, Guillermo, Navas, Placido, Spinazzi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519710/
https://www.ncbi.nlm.nih.gov/pubmed/37505079
http://dx.doi.org/10.7554/eLife.84710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519710/
https://www.ncbi.nlm.nih.gov/pubmed/37505079
http://dx.doi.org/10.7554/eLife.84710

Ejemplares similares