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Association of Neurofilament Light Chain With the Antidepressant Effects of Low-Dose Ketamine Infusion Among Patients With Treatment-Resistant Depression

BACKGROUND: The role of neurofilament light chain (NFL) in treatment-resistant depression (TRD) is unclear. Whether baseline NFL concentrations are associated with the antidepressant effects of low-dose ketamine infusion has not been determined. METHODS: The NFL concentrations of 71 patients with TR...

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Autores principales: Lin, Wei-Chen, Su, Tung-Ping, Li, Cheng-Ta, Wu, Hui-Ju, Bai, Ya-Mei, Liu, Yu-Li, Tu, Pei-Chi, Chen, Mu-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519806/
https://www.ncbi.nlm.nih.gov/pubmed/37490687
http://dx.doi.org/10.1093/ijnp/pyad045
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author Lin, Wei-Chen
Su, Tung-Ping
Li, Cheng-Ta
Wu, Hui-Ju
Bai, Ya-Mei
Liu, Yu-Li
Tu, Pei-Chi
Chen, Mu-Hong
author_facet Lin, Wei-Chen
Su, Tung-Ping
Li, Cheng-Ta
Wu, Hui-Ju
Bai, Ya-Mei
Liu, Yu-Li
Tu, Pei-Chi
Chen, Mu-Hong
author_sort Lin, Wei-Chen
collection PubMed
description BACKGROUND: The role of neurofilament light chain (NFL) in treatment-resistant depression (TRD) is unclear. Whether baseline NFL concentrations are associated with the antidepressant effects of low-dose ketamine infusion has not been determined. METHODS: The NFL concentrations of 71 patients with TRD and 17 healthy controls were assessed. Patients with TRD were randomly administered a single infusion of 0.5 mg/kg ketamine, 0.2 mg/kg ketamine, or normal saline. Depressive symptoms were assessed before infusion and sequentially at postinfusion timepoints (after 240 minutes and after 2–7 and 14 days) using the Hamilton Depression Rating Scale (HDRS). RESULTS: After adjustment for age, sex, and body mass index, patients with TRD were more likely to have higher concentrations of NFL than healthy controls (P < .001). A generalized estimating equation model with adjustments for infusion group, age, sex, body mass index, and baseline HDRS scores showed that baseline NFL concentrations were positively associated with subsequent HDRS scores following low-dose ketamine infusion (P = .038). DISCUSSION: Higher concentrations of NFL were observed among patients with TRD compared with healthy controls. Baseline NFL concentrations may predict the antidepressant effects of low-dose ketamine infusion.
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spelling pubmed-105198062023-09-27 Association of Neurofilament Light Chain With the Antidepressant Effects of Low-Dose Ketamine Infusion Among Patients With Treatment-Resistant Depression Lin, Wei-Chen Su, Tung-Ping Li, Cheng-Ta Wu, Hui-Ju Bai, Ya-Mei Liu, Yu-Li Tu, Pei-Chi Chen, Mu-Hong Int J Neuropsychopharmacol Regular Research Articles BACKGROUND: The role of neurofilament light chain (NFL) in treatment-resistant depression (TRD) is unclear. Whether baseline NFL concentrations are associated with the antidepressant effects of low-dose ketamine infusion has not been determined. METHODS: The NFL concentrations of 71 patients with TRD and 17 healthy controls were assessed. Patients with TRD were randomly administered a single infusion of 0.5 mg/kg ketamine, 0.2 mg/kg ketamine, or normal saline. Depressive symptoms were assessed before infusion and sequentially at postinfusion timepoints (after 240 minutes and after 2–7 and 14 days) using the Hamilton Depression Rating Scale (HDRS). RESULTS: After adjustment for age, sex, and body mass index, patients with TRD were more likely to have higher concentrations of NFL than healthy controls (P < .001). A generalized estimating equation model with adjustments for infusion group, age, sex, body mass index, and baseline HDRS scores showed that baseline NFL concentrations were positively associated with subsequent HDRS scores following low-dose ketamine infusion (P = .038). DISCUSSION: Higher concentrations of NFL were observed among patients with TRD compared with healthy controls. Baseline NFL concentrations may predict the antidepressant effects of low-dose ketamine infusion. Oxford University Press 2023-07-25 /pmc/articles/PMC10519806/ /pubmed/37490687 http://dx.doi.org/10.1093/ijnp/pyad045 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of CINP. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Regular Research Articles
Lin, Wei-Chen
Su, Tung-Ping
Li, Cheng-Ta
Wu, Hui-Ju
Bai, Ya-Mei
Liu, Yu-Li
Tu, Pei-Chi
Chen, Mu-Hong
Association of Neurofilament Light Chain With the Antidepressant Effects of Low-Dose Ketamine Infusion Among Patients With Treatment-Resistant Depression
title Association of Neurofilament Light Chain With the Antidepressant Effects of Low-Dose Ketamine Infusion Among Patients With Treatment-Resistant Depression
title_full Association of Neurofilament Light Chain With the Antidepressant Effects of Low-Dose Ketamine Infusion Among Patients With Treatment-Resistant Depression
title_fullStr Association of Neurofilament Light Chain With the Antidepressant Effects of Low-Dose Ketamine Infusion Among Patients With Treatment-Resistant Depression
title_full_unstemmed Association of Neurofilament Light Chain With the Antidepressant Effects of Low-Dose Ketamine Infusion Among Patients With Treatment-Resistant Depression
title_short Association of Neurofilament Light Chain With the Antidepressant Effects of Low-Dose Ketamine Infusion Among Patients With Treatment-Resistant Depression
title_sort association of neurofilament light chain with the antidepressant effects of low-dose ketamine infusion among patients with treatment-resistant depression
topic Regular Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519806/
https://www.ncbi.nlm.nih.gov/pubmed/37490687
http://dx.doi.org/10.1093/ijnp/pyad045
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