Cargando…

Shining light on the noradrenergic system

Despite decades of research on the noradrenergic system, our understanding of its impact on brain function and behavior remains incomplete. Traditional recording techniques are challenging to implement for investigating in vivo noradrenergic activity, due to the relatively small size and the positio...

Descripción completa

Detalles Bibliográficos
Autores principales: Tanguay, Emmeraude, Bouchard, Sarah-Julie, Lévesque, Martin, De Koninck, Paul, Breton-Provencher, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519836/
https://www.ncbi.nlm.nih.gov/pubmed/37766924
http://dx.doi.org/10.1117/1.NPh.10.4.044406
_version_ 1785109781367750656
author Tanguay, Emmeraude
Bouchard, Sarah-Julie
Lévesque, Martin
De Koninck, Paul
Breton-Provencher, Vincent
author_facet Tanguay, Emmeraude
Bouchard, Sarah-Julie
Lévesque, Martin
De Koninck, Paul
Breton-Provencher, Vincent
author_sort Tanguay, Emmeraude
collection PubMed
description Despite decades of research on the noradrenergic system, our understanding of its impact on brain function and behavior remains incomplete. Traditional recording techniques are challenging to implement for investigating in vivo noradrenergic activity, due to the relatively small size and the position in the brain of the locus coeruleus (LC), the primary location for noradrenergic neurons. However, recent advances in optical and fluorescent methods have enabled researchers to study the LC more effectively. Use of genetically encoded calcium indicators to image the activity of noradrenergic neurons and biosensors that monitor noradrenaline release with fluorescence can be an indispensable tool for studying noradrenergic activity. In this review, we examine how these methods are being applied to record the noradrenergic system in the rodent brain during behavior.
format Online
Article
Text
id pubmed-10519836
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Society of Photo-Optical Instrumentation Engineers
record_format MEDLINE/PubMed
spelling pubmed-105198362023-09-27 Shining light on the noradrenergic system Tanguay, Emmeraude Bouchard, Sarah-Julie Lévesque, Martin De Koninck, Paul Breton-Provencher, Vincent Neurophotonics Special Section: Frontiers in Neurophotonics Despite decades of research on the noradrenergic system, our understanding of its impact on brain function and behavior remains incomplete. Traditional recording techniques are challenging to implement for investigating in vivo noradrenergic activity, due to the relatively small size and the position in the brain of the locus coeruleus (LC), the primary location for noradrenergic neurons. However, recent advances in optical and fluorescent methods have enabled researchers to study the LC more effectively. Use of genetically encoded calcium indicators to image the activity of noradrenergic neurons and biosensors that monitor noradrenaline release with fluorescence can be an indispensable tool for studying noradrenergic activity. In this review, we examine how these methods are being applied to record the noradrenergic system in the rodent brain during behavior. Society of Photo-Optical Instrumentation Engineers 2023-09-26 2023-10 /pmc/articles/PMC10519836/ /pubmed/37766924 http://dx.doi.org/10.1117/1.NPh.10.4.044406 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle Special Section: Frontiers in Neurophotonics
Tanguay, Emmeraude
Bouchard, Sarah-Julie
Lévesque, Martin
De Koninck, Paul
Breton-Provencher, Vincent
Shining light on the noradrenergic system
title Shining light on the noradrenergic system
title_full Shining light on the noradrenergic system
title_fullStr Shining light on the noradrenergic system
title_full_unstemmed Shining light on the noradrenergic system
title_short Shining light on the noradrenergic system
title_sort shining light on the noradrenergic system
topic Special Section: Frontiers in Neurophotonics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519836/
https://www.ncbi.nlm.nih.gov/pubmed/37766924
http://dx.doi.org/10.1117/1.NPh.10.4.044406
work_keys_str_mv AT tanguayemmeraude shininglightonthenoradrenergicsystem
AT bouchardsarahjulie shininglightonthenoradrenergicsystem
AT levesquemartin shininglightonthenoradrenergicsystem
AT dekoninckpaul shininglightonthenoradrenergicsystem
AT bretonprovenchervincent shininglightonthenoradrenergicsystem