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Association of obesity profiles and metabolic health status with liver injury among US adult population in NHANES 1999–2016
The combined effect of obesity and metabolic abnormalities on liver injury is unclear. Aiming to address this knowledge gap, this cross-sectional study was conducted among 16,201 US adults. Multiple linear regression and logistic regression analyses were conducted to assess the associations of obesi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519960/ https://www.ncbi.nlm.nih.gov/pubmed/37749307 http://dx.doi.org/10.1038/s41598-023-43028-7 |
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author | Huang, Jing Gao, Tian Zhang, Huinan Wang, Xing |
author_facet | Huang, Jing Gao, Tian Zhang, Huinan Wang, Xing |
author_sort | Huang, Jing |
collection | PubMed |
description | The combined effect of obesity and metabolic abnormalities on liver injury is unclear. Aiming to address this knowledge gap, this cross-sectional study was conducted among 16,201 US adults. Multiple linear regression and logistic regression analyses were conducted to assess the associations of obesity profiles, metabolic health status, and weight change with the levels of liver enzymes. The analysis revealed that general obesity and abdominal obesity were positively associated with the levels of liver enzymes and the prevalence of abnormal liver enzymes (P and P(trend) < 0.05). The associations remained significant in both metabolically healthy and metabolically unhealthy subgroups. Additionally, the liver injury index levels of the metabolically unhealthy participants were higher than those of the metabolically healthy individuals within the non-obese, overweight/pre-abdominal obesity, and general/abdominal obesity subgroups (P and P(trend) < 0.05). Furthermore, the subgroup characterized by general/abdominal obesity and metabolic dysfunction exhibited the most robust association with the liver injury index compared to all other subgroups examined. In addition, positive associations were observed between the 1-year and 10-year weight changes and the levels of liver injury indicators (P and P(trend) < 0.05). In conclusion, this study demonstrates that both obesity and metabolic impairment are independently associated with liver injury, and their combined presence have an additional adverse effect on liver health. These findings underscore the importance of addressing both obesity and metabolic dysfunction in order to mitigate the risk of liver injury. |
format | Online Article Text |
id | pubmed-10519960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105199602023-09-27 Association of obesity profiles and metabolic health status with liver injury among US adult population in NHANES 1999–2016 Huang, Jing Gao, Tian Zhang, Huinan Wang, Xing Sci Rep Article The combined effect of obesity and metabolic abnormalities on liver injury is unclear. Aiming to address this knowledge gap, this cross-sectional study was conducted among 16,201 US adults. Multiple linear regression and logistic regression analyses were conducted to assess the associations of obesity profiles, metabolic health status, and weight change with the levels of liver enzymes. The analysis revealed that general obesity and abdominal obesity were positively associated with the levels of liver enzymes and the prevalence of abnormal liver enzymes (P and P(trend) < 0.05). The associations remained significant in both metabolically healthy and metabolically unhealthy subgroups. Additionally, the liver injury index levels of the metabolically unhealthy participants were higher than those of the metabolically healthy individuals within the non-obese, overweight/pre-abdominal obesity, and general/abdominal obesity subgroups (P and P(trend) < 0.05). Furthermore, the subgroup characterized by general/abdominal obesity and metabolic dysfunction exhibited the most robust association with the liver injury index compared to all other subgroups examined. In addition, positive associations were observed between the 1-year and 10-year weight changes and the levels of liver injury indicators (P and P(trend) < 0.05). In conclusion, this study demonstrates that both obesity and metabolic impairment are independently associated with liver injury, and their combined presence have an additional adverse effect on liver health. These findings underscore the importance of addressing both obesity and metabolic dysfunction in order to mitigate the risk of liver injury. Nature Publishing Group UK 2023-09-25 /pmc/articles/PMC10519960/ /pubmed/37749307 http://dx.doi.org/10.1038/s41598-023-43028-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Huang, Jing Gao, Tian Zhang, Huinan Wang, Xing Association of obesity profiles and metabolic health status with liver injury among US adult population in NHANES 1999–2016 |
title | Association of obesity profiles and metabolic health status with liver injury among US adult population in NHANES 1999–2016 |
title_full | Association of obesity profiles and metabolic health status with liver injury among US adult population in NHANES 1999–2016 |
title_fullStr | Association of obesity profiles and metabolic health status with liver injury among US adult population in NHANES 1999–2016 |
title_full_unstemmed | Association of obesity profiles and metabolic health status with liver injury among US adult population in NHANES 1999–2016 |
title_short | Association of obesity profiles and metabolic health status with liver injury among US adult population in NHANES 1999–2016 |
title_sort | association of obesity profiles and metabolic health status with liver injury among us adult population in nhanes 1999–2016 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519960/ https://www.ncbi.nlm.nih.gov/pubmed/37749307 http://dx.doi.org/10.1038/s41598-023-43028-7 |
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