Identification of pyroptosis-related subtypes and comprehensive analysis of characteristics of the tumor microenvironment infiltration in clear cell renal cell carcinoma

Pyroptosis is a kind of programmed cell death triggered by the inflammasome. Growing evidence has revealed the crucial utility of pyroptosis in tumors. However, the potential mechanism of pyroptosis in clear cell renal cell carcinoma (ccRCC) is still unclear. In this research, we systematically anal...

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Autores principales: Zeng, Jiayi, Zhu, Ping, Tang, Yanlin, Zhang, Changzheng, Ye, Chujin, Cheng, Shouyu, Tian, Kaiwen, Yang, Bowen, Zeng, Weinan, Liu, Yanjun, Xian, Zhiyong, Yu, Yuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519968/
https://www.ncbi.nlm.nih.gov/pubmed/37749171
http://dx.doi.org/10.1038/s41598-023-43023-y
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author Zeng, Jiayi
Zhu, Ping
Tang, Yanlin
Zhang, Changzheng
Ye, Chujin
Cheng, Shouyu
Tian, Kaiwen
Yang, Bowen
Zeng, Weinan
Liu, Yanjun
Xian, Zhiyong
Yu, Yuming
author_facet Zeng, Jiayi
Zhu, Ping
Tang, Yanlin
Zhang, Changzheng
Ye, Chujin
Cheng, Shouyu
Tian, Kaiwen
Yang, Bowen
Zeng, Weinan
Liu, Yanjun
Xian, Zhiyong
Yu, Yuming
author_sort Zeng, Jiayi
collection PubMed
description Pyroptosis is a kind of programmed cell death triggered by the inflammasome. Growing evidence has revealed the crucial utility of pyroptosis in tumors. However, the potential mechanism of pyroptosis in clear cell renal cell carcinoma (ccRCC) is still unclear. In this research, we systematically analyze the genetic and transcriptional alterations of pyroptosis-related genes (PRGs) in ccRCC, identify pyroptosis-related subtypes, analyze the clinical and microenvironmental differences among different subtypes, develop a corresponding prognostic model to predict the prognosis of patients, and interpret the effect of pyroptosis on ccRCC microenvironment. This study provides a new perspective for a comprehensive understanding of the role of pyroptosis in ccRCC and its impact on the immune microenvironment, and a reliable scoring system was established to predict patients’ prognosis.
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spelling pubmed-105199682023-09-27 Identification of pyroptosis-related subtypes and comprehensive analysis of characteristics of the tumor microenvironment infiltration in clear cell renal cell carcinoma Zeng, Jiayi Zhu, Ping Tang, Yanlin Zhang, Changzheng Ye, Chujin Cheng, Shouyu Tian, Kaiwen Yang, Bowen Zeng, Weinan Liu, Yanjun Xian, Zhiyong Yu, Yuming Sci Rep Article Pyroptosis is a kind of programmed cell death triggered by the inflammasome. Growing evidence has revealed the crucial utility of pyroptosis in tumors. However, the potential mechanism of pyroptosis in clear cell renal cell carcinoma (ccRCC) is still unclear. In this research, we systematically analyze the genetic and transcriptional alterations of pyroptosis-related genes (PRGs) in ccRCC, identify pyroptosis-related subtypes, analyze the clinical and microenvironmental differences among different subtypes, develop a corresponding prognostic model to predict the prognosis of patients, and interpret the effect of pyroptosis on ccRCC microenvironment. This study provides a new perspective for a comprehensive understanding of the role of pyroptosis in ccRCC and its impact on the immune microenvironment, and a reliable scoring system was established to predict patients’ prognosis. Nature Publishing Group UK 2023-09-25 /pmc/articles/PMC10519968/ /pubmed/37749171 http://dx.doi.org/10.1038/s41598-023-43023-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zeng, Jiayi
Zhu, Ping
Tang, Yanlin
Zhang, Changzheng
Ye, Chujin
Cheng, Shouyu
Tian, Kaiwen
Yang, Bowen
Zeng, Weinan
Liu, Yanjun
Xian, Zhiyong
Yu, Yuming
Identification of pyroptosis-related subtypes and comprehensive analysis of characteristics of the tumor microenvironment infiltration in clear cell renal cell carcinoma
title Identification of pyroptosis-related subtypes and comprehensive analysis of characteristics of the tumor microenvironment infiltration in clear cell renal cell carcinoma
title_full Identification of pyroptosis-related subtypes and comprehensive analysis of characteristics of the tumor microenvironment infiltration in clear cell renal cell carcinoma
title_fullStr Identification of pyroptosis-related subtypes and comprehensive analysis of characteristics of the tumor microenvironment infiltration in clear cell renal cell carcinoma
title_full_unstemmed Identification of pyroptosis-related subtypes and comprehensive analysis of characteristics of the tumor microenvironment infiltration in clear cell renal cell carcinoma
title_short Identification of pyroptosis-related subtypes and comprehensive analysis of characteristics of the tumor microenvironment infiltration in clear cell renal cell carcinoma
title_sort identification of pyroptosis-related subtypes and comprehensive analysis of characteristics of the tumor microenvironment infiltration in clear cell renal cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519968/
https://www.ncbi.nlm.nih.gov/pubmed/37749171
http://dx.doi.org/10.1038/s41598-023-43023-y
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