Evolution of lasR mutants in polymorphic Pseudomonas aeruginosa populations facilitates chronic infection of the lung

Chronic infection with the bacterial pathogen Pseudomonas aeruginosa often leads to coexistence of heterogeneous populations carrying diverse mutations. In particular, loss-of-function mutations affecting the quorum-sensing regulator LasR are often found in bacteria isolated from patients with lung...

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Detalles Bibliográficos
Autores principales: Zhao, Kelei, Yang, Xiting, Zeng, Qianglin, Zhang, Yige, Li, Heyue, Yan, Chaochao, Li, Jing Shirley, Liu, Huan, Du, Liangming, Wu, Yi, Huang, Gui, Huang, Ting, Zhang, Yamei, Zhou, Hui, Wang, Xinrong, Chu, Yiwen, Zhou, Xikun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519970/
https://www.ncbi.nlm.nih.gov/pubmed/37749088
http://dx.doi.org/10.1038/s41467-023-41704-w

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