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Driving forces behind phase separation of the carboxy-terminal domain of RNA polymerase II

Eukaryotic gene regulation and pre-mRNA transcription depend on the carboxy-terminal domain (CTD) of RNA polymerase (Pol) II. Due to its highly repetitive, intrinsically disordered sequence, the CTD enables clustering and phase separation of Pol II. The molecular interactions that drive CTD phase se...

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Detalles Bibliográficos
Autores principales:	Flores-Solis, David, Lushpinskaia, Irina P., Polyansky, Anton A., Changiarath, Arya, Boehning, Marc, Mirkovic, Milana, Walshe, James, Pietrek, Lisa M., Cramer, Patrick, Stelzl, Lukas S., Zagrovic, Bojan, Zweckstetter, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519987/ https://www.ncbi.nlm.nih.gov/pubmed/37749095 http://dx.doi.org/10.1038/s41467-023-41633-8

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